职业烹饪与葡萄膜黑色素瘤风险：一项荟萃分析

Occupational cooking and risk of uveal melanoma: a meta-analysis.

作者信息

Ge Yi-Rui, Tian Nong, Lu Yan, Wu Yong, Hu Qin-Rui, Huang Zheng-Ping

机构信息

Department of Ophthalmology, Jinling Hospital of Nanjing, Nanjing, China.

出版信息

Asian Pac J Cancer Prev. 2012;13(10):4927-30. doi: 10.7314/apjcp.2012.13.10.4927.

DOI:10.7314/apjcp.2012.13.10.4927

PMID:23244083

Abstract

BACKGROUND

Many observational studies have assessed the possible association between occupational cooking and uveal melanoma risk, but reported results are controversial. Our goal was to evaluate the association between occupational cooking and uveal melanoma risk by conducting a meta-analysis of observational studies.

METHODS

PubMed, EMBASE, and Web of Science were searched through June 2012 to identify all eligible studies. The pooled odds ratio (OR) with its 95% confidence interval (95%CI) was used to evaluate this association. Either a fixed- or a random-effects model were used to calculate pooled ORs.

RESULTS

Five case-control studies involving a total of 1,199 cases and 6,927 controls were included in the meta-analysis. Overall, occupational cooking was associated with an increased risk of uveal melanoma (OR: 1.81, 95%CI 1.33-2.46, P < 0.001). Subgroup analysis by gender suggested occupational cooking was associated with increased risk of uveal melanoma in both men (OR: 2.16, 95%CI 1.06-4.40, P = 0.034) and women (OR: 1.92, 95%CI 1.19-3.10, P = 0.008).

CONCLUSION

This meta-analysis suggests that occupational cooking is associated with an increased risk of uveal melanoma in both men and women.

摘要

背景

许多观察性研究评估了职业烹饪与葡萄膜黑色素瘤风险之间可能存在的关联，但报告的结果存在争议。我们的目标是通过对观察性研究进行荟萃分析来评估职业烹饪与葡萄膜黑色素瘤风险之间的关联。

方法

检索了截至2012年6月的PubMed、EMBASE和科学网，以确定所有符合条件的研究。采用合并比值比（OR）及其95%置信区间（95%CI）来评估这种关联。使用固定效应模型或随机效应模型计算合并OR值。

结果

荟萃分析纳入了5项病例对照研究，共涉及1199例病例和6927例对照。总体而言，职业烹饪与葡萄膜黑色素瘤风险增加相关（OR：1.81，95%CI 1.33 - 2.46，P < 0.001）。按性别进行的亚组分析表明，职业烹饪与男性（OR：2.16，95%CI 1.06 - 4.40，P = 0.034）和女性（OR：1.92，95%CI 1.19 - 3.10，P = 0.008）的葡萄膜黑色素瘤风险增加均相关。