Shah Chirag P, Weis Ezekiel, Lajous Martin, Shields Jerry A, Shields Carol L
Harvard School of Public Health, Boston, Massachusetts, USA.
Ophthalmology. 2005 Sep;112(9):1599-607. doi: 10.1016/j.ophtha.2005.04.020.
To examine the association between ultraviolet light exposure and uveal melanoma.
Meta-analysis.
A review of 133 published reports on risk factors for uveal melanoma revealed 12 studies that provided sufficient information to calculate odds ratios (ORs) and standard errors for ultraviolet light exposure factors. Data from these studies were extracted and categorized into intermittent ultraviolet exposure factors (welding, outdoor leisure, photokeratitis) and chronic ultraviolet exposure factors (occupational sunlight exposure, birth latitude, lifetime ultraviolet exposure index). Summary statistics were calculated for all risk factors reported by > or =4 independent studies.
Welding, outdoor leisure, photokeratitis, occupational sunlight exposure, birth latitude, and lifetime ultraviolet exposure index.
For intermittent ultraviolet exposure, welding was found to be a significant risk factor (5 studies, 1137 cases; OR, 2.05 [95% confidence interval [CI], 1.20-3.51]). Outdoor leisure was found to be nonsignificant (4 studies, 1332 cases; OR, 0.86 [95% CI, 0.71-1.04]). Photokeratitis conferred susceptibility in 3 reports studying this variable, but there were too few studies to validate meta-analyses. For chronic ultraviolet exposure, meta-analysis found occupational sunlight exposure to be a borderline nonsignificant risk factor for development of uveal melanoma (4 studies, 572 cases; OR, 1.37 [95% CI, 0.96-1.96]). Latitude of birth was found to be nonsignificant (5 studies, 1765 cases; OR, 1.08 [95% CI, 0.67-1.74]).
This meta-analysis yielded inconsistent results associating ultraviolet light with development of uveal melanoma. There was evidence implicating welding as a possible risk factor for uveal melanoma.
探讨紫外线暴露与葡萄膜黑色素瘤之间的关联。
荟萃分析。
对133篇已发表的关于葡萄膜黑色素瘤危险因素的报告进行回顾，发现12项研究提供了足够信息来计算紫外线暴露因素的比值比（OR）和标准误。提取这些研究的数据，并分为间歇性紫外线暴露因素（焊接、户外休闲、电光性眼炎）和慢性紫外线暴露因素（职业性阳光暴露、出生纬度、终生紫外线暴露指数）。对≥4项独立研究报告的所有危险因素计算汇总统计量。
焊接、户外休闲、电光性眼炎、职业性阳光暴露、出生纬度和终生紫外线暴露指数。
对于间歇性紫外线暴露，发现焊接是一个显著危险因素（5项研究，1137例；OR，2.05[95%置信区间（CI），1.20 - 3.51]）。户外休闲未显示显著意义（4项研究，1332例；OR，0.86[95%CI，0.71 - 1.04]）。在3项研究该变量的报告中，电光性眼炎显示有易感性，但研究数量太少无法验证荟萃分析结果。对于慢性紫外线暴露，荟萃分析发现职业性阳光暴露是葡萄膜黑色素瘤发生的边缘性非显著危险因素（4项研究，572例；OR，1.37[95%CI，0.96 - 1.96]）。出生纬度未显示显著意义（5项研究，1765例；OR，1.08[95%CI，0.67 - 1.74]）。
这项荟萃分析得出关于紫外线与葡萄膜黑色素瘤发生之间关联的结果不一致。有证据表明焊接可能是葡萄膜黑色素瘤的一个危险因素。
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