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表观遗传学与衰老。

Epigenetics and aging.

机构信息

Department of Cell Biology, University of Calabria, 87036 Rende, Italy.

出版信息

Maturitas. 2013 Feb;74(2):130-6. doi: 10.1016/j.maturitas.2012.11.005. Epub 2012 Dec 12.

Abstract

Over the past two decades, a growing interest on the research of the biological basis of human longevity has emerged, in order to clarify the intricacy of biological and environmental factors affecting (together with stochastic factors) the quality and the rate of human aging. These researches have outlined a complex scenario in which epigenetic marks, such as DNA methylation and numerous histone modifications, are emerging as important factors of the overall variation in life expectancy. In fact, epigenetic marks, that are responsible of the establishment of specific expression programs and of genome stability, represent a "drawbridge" across genetic, environmental and stochastic factors. In this review we provide an overview on the current knowledge and the general features of the epigenetic modifications characterizing the aging process.

摘要

在过去的二十年中,人们对人类长寿的生物学基础的研究产生了浓厚的兴趣,旨在阐明影响(与随机因素一起)人类衰老质量和速度的生物学和环境因素的复杂性。这些研究勾勒出了一个复杂的情景,其中表观遗传标记,如 DNA 甲基化和许多组蛋白修饰,作为预期寿命总体变化的重要因素出现。事实上,负责建立特定表达程序和基因组稳定性的表观遗传标记是跨越遗传、环境和随机因素的“桥梁”。在这篇综述中,我们概述了描述衰老过程的表观遗传修饰的现有知识和一般特征。

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