Department of Physiology, Faculty of Medicine, Urmia Medical University, Urmia, Iran.
Respir Physiol Neurobiol. 2013 Feb 1;185(3):593-9. doi: 10.1016/j.resp.2012.11.017. Epub 2012 Dec 13.
Twenty-fourmale rats were divided into three groups: Control (C), non-treated diabetic (NTD), and vitamin E-treated diabetic (VETD) groups. After 6 weeks, we evaluated the changes in the alveolar epithelium, alveolar septum thickness, Hcy, and cathepsin G levels in the lung tissue and plasma serine protease inhibitor levels.The results revealed a significant increase in alveolar septum thickness, a high number of type II pneumocytes, high number of glycogen granules, increased vascular elastic membrane thickness, and increased Hcy and cathepsin G levels in the diabetic rats. Plasma level of serine protease inhibitors showed a significant decrease in the NTD animals. The vitamin E-treated rats showed significant amelioration of lung tissue changes, as well as restoration of high cathepsin G, Hcy levels, and serine protease inhibitors when compared to the control rats. These results suggest that diabetes induces lung tissue changes that may be stimulated by Hcy and cathepsin G mediated oxidative stress by, and protective effect could be achieved by using vitamin E.
对照组（C）、未治疗的糖尿病组（NTD）和维生素 E 治疗的糖尿病组（VETD）。6 周后，我们评估了肺组织和血浆中丝氨酸蛋白酶抑制剂水平的肺泡上皮、肺泡间隔厚度、Hcy 和组织蛋白酶 G 水平的变化。结果显示，糖尿病大鼠的肺泡间隔厚度显著增加，II 型肺泡细胞数量增加，糖原颗粒数量增加，血管弹性膜厚度增加，Hcy 和组织蛋白酶 G 水平升高。NTD 动物的血浆丝氨酸蛋白酶抑制剂水平显著降低。与对照组相比，维生素 E 治疗的大鼠的肺组织变化明显改善，同时高组织蛋白酶 G、Hcy 水平和丝氨酸蛋白酶抑制剂也得到恢复。这些结果表明，糖尿病可诱导肺组织变化，这些变化可能是由 Hcy 和组织蛋白酶 G 介导的氧化应激刺激的，而使用维生素 E 可达到保护作用。
