Ilkhanizadeh Behrouz, Shirpoor Alireza, Khadem Ansari Mohamad Hasan, Nemati Samira, Rasmi Yusef
Department of Pathology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.
Department of Physiology, Urmia University of Medical Sciences Faculty of Medicine, Urmia, Iran.
Diabetes Metab J. 2016 Feb;40(1):46-53. doi: 10.4093/dmj.2016.40.1.46.
Diabetic cardiomyopathy is an important causal factor in morbidity and mortality among diabetic patients, and currently, no effective means are available to reverse its pathological progress. The purpose of the present study was to investigate the effect of ginger extract on apolipoproteins (apo) A and B, hyperhomocysteinemia, cathepsin G and leptin changes, as well as cardiac fibrosis and heart muscle cell proliferation under hyperglycemic conditions in vivo.
Twenty-four male Wistar rats were divided into three groups, namely: control, non-treated diabetic, and ginger extract-treated diabetic groups. The ginger extract-treated diabetic group received a 50 mg daily dose of ginger extract intragastrically for 6 weeks.
The results revealed concurrent significant increases in plasma C-reactive protein (CRP), homocysteine (Hcy), cathepsin G and apoB levels and decreases in apoA and leptin levels in the non-treated diabetic group compared to the control group. Moreover, heart structural changes, including fibrosis and heart muscle cell proliferation, were observed in non-treated diabetic rats compared to the control rats. Significant amelioration of changes in the heart structure together with restoration of the elevated levels of Hcy and CRP, leptin, cathepsin G, and apoA and B were found in the ginger extract-treated diabetic group compared to the non-treated diabetic group.
The findings indicated that ginger extract significantly reduces heart structural abnormalities in diabetic rats and that these effects might be associated with improvements in serum apo, leptin, cathepsin G, and Hcy levels and with the antioxidant properties of ginger extract.
糖尿病性心肌病是糖尿病患者发病和死亡的重要病因，目前尚无有效的方法来逆转其病理进程。本研究的目的是在体内高血糖条件下，研究生姜提取物对载脂蛋白（apo）A和B、高同型半胱氨酸血症、组织蛋白酶G和瘦素变化以及心脏纤维化和心肌细胞增殖的影响。
将24只雄性Wistar大鼠分为三组，即：对照组、未治疗的糖尿病组和生姜提取物治疗的糖尿病组。生姜提取物治疗的糖尿病组每天经胃给予50mg生姜提取物，持续6周。
结果显示，与对照组相比，未治疗的糖尿病组血浆C反应蛋白（CRP）、同型半胱氨酸（Hcy）、组织蛋白酶G和apoB水平同时显著升高，而apoA和瘦素水平降低。此外，与对照大鼠相比，在未治疗的糖尿病大鼠中观察到心脏结构变化，包括纤维化和心肌细胞增殖。与未治疗的糖尿病组相比，生姜提取物治疗的糖尿病组心脏结构变化得到显著改善，同时Hcy和CRP、瘦素、组织蛋白酶G以及apoA和B的升高水平恢复正常。
研究结果表明，生姜提取物可显著减轻糖尿病大鼠的心脏结构异常，这些作用可能与血清载脂蛋白、瘦素、组织蛋白酶G和Hcy水平的改善以及生姜提取物的抗氧化特性有关。
