• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

气相色谱-质谱联用法定量检测人脑脊液中的N-乙酰天门冬氨酸

Determination of N-acetylaspartic acid in human cerebrospinal fluid by gas chromatography-mass spectrometry.

作者信息

Swahn C G

机构信息

Department of Psychiatry and Psychology, Karolinska Institutet, Stockholm, Sweden.

出版信息

J Neurochem. 1990 May;54(5):1584-8. doi: 10.1111/j.1471-4159.1990.tb01208.x.

DOI:10.1111/j.1471-4159.1990.tb01208.x
PMID:2324740
Abstract

N-Acetyl-L-aspartic acid was identified and determined in human cerebrospinal fluid. The concentration in lumbar fluid was about 2 nmol/ml and about 20 nmol/ml in ventricular fluid. There was no difference between healthy subjects and schizophrenic patients.

摘要

在人类脑脊液中鉴定并测定了N-乙酰-L-天冬氨酸。腰段脑脊液中的浓度约为2纳摩尔/毫升，脑室液中的浓度约为20纳摩尔/毫升。健康受试者和精神分裂症患者之间没有差异。

相似文献

1
Determination of N-acetylaspartic acid in human cerebrospinal fluid by gas chromatography-mass spectrometry.气相色谱-质谱联用法定量检测人脑脊液中的N-乙酰天门冬氨酸
J Neurochem. 1990 May;54(5):1584-8. doi: 10.1111/j.1471-4159.1990.tb01208.x.
2
N-acetylaspartic acid (NAA) and N-acetylaspartylglutamic acid (NAAG) in human ventricular, subarachnoid, and lumbar cerebrospinal fluid.人心室、蛛网膜下腔和腰椎脑脊液中的N-乙酰天门冬氨酸（NAA）和N-乙酰天门冬氨酰谷氨酸（NAAG）
Neurochem Res. 1999 Oct;24(10):1249-61. doi: 10.1023/a:1020973023059.
3
Sudden infant death syndrome: organic acid profiles in cerebrospinal fluid from 47 children and the occurrence of N-acetylaspartic acid.
J Inherit Metab Dis. 1990;13(3):330-2. doi: 10.1007/BF01799387.
4
N-acetylaspartic acid in cerebrospinal fluid of multiple sclerosis patients determined by gas-chromatography-mass spectrometry.采用气相色谱-质谱联用技术测定多发性硬化症患者脑脊液中的N-乙酰天门冬氨酸。
J Neurol. 2007 May;254(5):631-7. doi: 10.1007/s00415-006-0415-5. Epub 2007 Apr 6.
5
Gas chromatographic-mass spectrometric determination of myo-inositol in human cerebrospinal fluid.气相色谱-质谱法测定人脑脊液中的肌醇
J Neurochem. 1985 Aug;45(2):331-4. doi: 10.1111/j.1471-4159.1985.tb03992.x.
6
N-acetylaspartic aciduria in a child with a progressive cerebral atrophy.一名患有进行性脑萎缩儿童的N-乙酰天门冬氨酸尿症
Clin Chim Acta. 1986 Aug 15;158(3):217-27. doi: 10.1016/0009-8981(86)90285-8.
7
Quantification of N-acetyl-L-aspartic acid in urine by isotope dilution gas chromatography-mass spectrometry.采用同位素稀释气相色谱-质谱法对尿液中的N-乙酰-L-天冬氨酸进行定量分析。
J Inherit Metab Dis. 1992;15(1):97-104. doi: 10.1007/BF01800351.
8
Stable isotope dilution analysis of N-acetylaspartic acid in CSF, blood, urine and amniotic fluid: accurate postnatal diagnosis and the potential for prenatal diagnosis of Canavan disease.脑脊液、血液、尿液和羊水中N-乙酰天门冬氨酸的稳定同位素稀释分析：Canavan病的准确产后诊断及产前诊断潜力
J Inherit Metab Dis. 1991;14(5):653-60. doi: 10.1007/BF01799929.
9
Quantitative measurement of N-acetyl-L-aspartic acid in urine by gas chromatography with negative-ion chemical ionization mass spectrometry.采用负离子化学电离质谱的气相色谱法对尿液中N-乙酰-L-天冬氨酸进行定量测定。
J Chromatogr. 1992 Jul 1;578(1):116-9. doi: 10.1016/0378-4347(92)80232-f.
10
Gas chromatography and mass spectrometry of N-(phosphonacetyl)-L-aspartic acid.N-（膦酰基乙酰基）-L-天冬氨酸的气相色谱和质谱分析
J Chromatogr. 1978 Apr 1;151(1):71-4. doi: 10.1016/s0021-9673(01)91988-0.

引用本文的文献

1
Biomarkers in the cerebrospinal fluid of patients with psychotic disorders compared to healthy controls: a systematic review and meta-analysis.精神障碍患者与健康对照者脑脊液中的生物标志物：系统评价和荟萃分析。
Mol Psychiatry. 2023 Jun;28(6):2277-2290. doi: 10.1038/s41380-023-02059-2. Epub 2023 May 11.
2
N-Acetyl-aspartylglutamate (NAAG) in human cerebrospinal fluid: Determination by high performance liquid chromatography, and influence of biological variables.人脑脊液中的 N-乙酰天冬氨酰谷氨酸（NAAG）：高效液相色谱法测定及生物学变量的影响。
Amino Acids. 1995 Jun;9(2):175-84. doi: 10.1007/BF00805838.
3
N-acetylaspartic acid (NAA) and N-acetylaspartylglutamic acid (NAAG) in human ventricular, subarachnoid, and lumbar cerebrospinal fluid.
人心室、蛛网膜下腔和腰椎脑脊液中的N-乙酰天门冬氨酸（NAA）和N-乙酰天门冬氨酰谷氨酸（NAAG）
Neurochem Res. 1999 Oct;24(10):1249-61. doi: 10.1023/a:1020973023059.
4
Canavan disease. Analysis of the nature of the metabolic lesions responsible for development of the observed clinical symptoms.卡纳万病。对导致所观察到的临床症状发展的代谢性病变性质的分析。
J Mol Neurosci. 1997 Oct;9(2):109-25. doi: 10.1007/BF02736855.
5
Quantification of N-acetyl-L-aspartic acid in urine by isotope dilution gas chromatography-mass spectrometry.采用同位素稀释气相色谱-质谱法对尿液中的N-乙酰-L-天冬氨酸进行定量分析。
J Inherit Metab Dis. 1992;15(1):97-104. doi: 10.1007/BF01800351.