Swahn C G
J Neurochem. 1985 Aug;45(2):331-4. doi: 10.1111/j.1471-4159.1985.tb03992.x.
The concentration of free myo-inositol in CSF was determined with a gas chromatographic-mass spectrometric method using deuterated myo-inositol as an internal standard after conversion to the hexa-O-acetyl derivative with acetic anhydride and pyridine. Twenty microliters of CSF is sufficient for the analysis which has a coefficient of variation of 9%. Identical analytical results were obtained on two different mass numbers. Schizophrenic patients were compared with healthy control persons. In addition, patients with rheumatoid arthritis or with neurological illnesses were studied. No consistent differences related to the illness could be found. The mean concentration of myo-inositol was about 25 micrograms/ml. Treatment of schizophrenic patients with chlorpromazine or sulpiride had no significant effect on the concentration of myo-inositol in CSF.
采用气相色谱 - 质谱法，以氘代肌醇为内标，在与乙酸酐和吡啶反应转化为六 - O - 乙酰衍生物后，测定脑脊液中游离肌醇的浓度。20微升脑脊液足以进行分析，其变异系数为9%。在两个不同的质量数上获得了相同的分析结果。将精神分裂症患者与健康对照者进行了比较。此外，还对类风湿性关节炎患者或神经系统疾病患者进行了研究。未发现与疾病相关的一致差异。肌醇的平均浓度约为25微克/毫升。用氯丙嗪或舒必利治疗精神分裂症患者对脑脊液中肌醇的浓度没有显著影响。
