Bruce N G, Cook D G, Shaper A G, Thomson A G
Department of Clinical Epidemiology and General Practice, Royal Free Hospital School of Medicine, London, England.
J Clin Epidemiol. 1990;43(4):385-98. doi: 10.1016/0895-4356(90)90124-8.
Geographical variations in blood pressure have been studied using an automatic sphygmomanometer in 2596 men and women aged 25-29, 40-44 and 55-59 living in nine British towns. In males aged 40-59, systolic blood pressure showed a range in age-adjusted town means of 9.0 mmHg (p less than 0.05); in females the difference of 8.6 mmHg was not significant (p = 0.14). Mean arterial pressure (MAP) and diastolic at age 40-59 were significantly different between towns for both sexes. Differences at age 25-29 were of a similar magnitude, and the mean town blood pressures at 25-29 correlated highly with those at 40-59 [systolic; males r = 0.74 (p less than 0.05), females r = 0.65 (p = 0.059)]. The ranking of town blood pressures in an earlier study was reflected in the present study, but stronger associations were observed with cardiovascular mortality. It is concluded that geographical blood pressure variations in Britain are established by age 25-29 years.
研究人员使用自动血压计,对居住在英国9个城镇的2596名年龄在25 - 29岁、40 - 44岁和55 - 59岁的男性和女性的血压地理差异进行了研究。在40 - 59岁的男性中,经年龄调整后的各城镇收缩压均值范围为9.0 mmHg(p < 0.05);在女性中,8.6 mmHg的差异不显著(p = 0.14)。40 - 59岁时,男女两性的平均动脉压(MAP)和舒张压在不同城镇之间均存在显著差异。25 - 29岁时的差异幅度相似,且25 - 29岁时各城镇的平均血压与40 - 59岁时的平均血压高度相关[收缩压;男性r = 0.74(p < 0.05),女性r = 0.65(p = 0.059)]。早期研究中各城镇血压的排名在本研究中得到了体现,但与心血管死亡率的关联更强。研究得出结论,英国血压的地理差异在25 - 29岁时就已形成。