儿童多形性胶质母细胞瘤：单机构经验
Pediatric glioblastoma multiforme: A single-institution experience.
作者信息
Ansari Mansour, Nasrolahi Hamid, Kani Amir-Abbas, Mohammadianpanah Mohammad, Ahmadloo Niloofar, Omidvari Shapour, Mosalaei Ahmad
机构信息
Department of Radiation Oncology, Student Research Committee, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran.
出版信息
Indian J Med Paediatr Oncol. 2012 Jul;33(3):155-60. doi: 10.4103/0971-5851.103142.
Abstract
BACKGROUND
Glioblastoma multiforme (GBM) is the most common astrocytoma in adults and has a poor prognosis, with a median survival of about 12 months. But, it is rare in children. We report our experience on the pediatric population (20 years or younger) with GBM.
PATIENTS AND METHODS
Twenty-three patients with GBM who were treated at our hospital during 1990-2008 were evaluated.
RESULTS
The mean age was 15.2 years, and the majority of them (14/23) were male. All had received radiotherapy and some had also received chemotherapy. The mean survival was 16.0 months. Two cases survived more than 5 years. Age, radiation dose and performance status were significantly related to survival.
CONCLUSION
GBM in pediatric patients were not very common in our center, and prognosis was unfavorable.
摘要
背景
多形性胶质母细胞瘤（GBM）是成人中最常见的星形细胞瘤，预后较差，中位生存期约为12个月。但在儿童中较为罕见。我们报告了我们对儿童（20岁及以下）GBM患者的治疗经验。
患者与方法
对1990年至2008年期间在我院接受治疗的23例GBM患者进行了评估。
结果
平均年龄为15.2岁，大多数患者（14/23）为男性。所有患者均接受了放疗，部分患者还接受了化疗。平均生存期为16.0个月。2例患者存活超过5年。年龄、放疗剂量和功能状态与生存期显著相关。
结论
在我们中心，儿童GBM患者并不常见，预后不佳。
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