Section of Dermatology, Department of Medicine, University of the Philippines - Philippine General Hospital, Taft Avenue, Manila 1000, Philippines.
Expert Rev Med Devices. 2012 Nov;9(6):641-50. doi: 10.1586/erd.12.56.
Keloids and hypertrophic scars affect millions of patients. In spite of the widely accepted clinical efficacy of pulsed dye laser (PDL) in the treatment of these scars, a summary of the evidence comparing the use of PDL with conventional treatment modalities has not yet been undertaken. The objective of this review is to assess the efficacy of 585-nm PDL in the treatment of hypertrophic and keloid scars compared with conventional treatment modalities. This review includes eight randomized controlled trials. Results show that treatment with PDL may be superior to conventional modalities in improving overall scar appearance, but results were comparable when scar parameters were evaluated separately. More parallel comparison trials with standardized methods of treatment and outcome assessment are recommended to evaluate long-term treatment effects and recurrence rates.
瘢痕疙瘩和增生性瘢痕影响着数以百万计的患者。尽管脉冲染料激光（PDL）在治疗这些瘢痕方面的临床疗效已被广泛认可，但尚未对比较 PDL 与传统治疗方法的证据进行总结。本综述的目的是评估 585nm PDL 治疗增生性瘢痕和瘢痕疙瘩的疗效与传统治疗方法相比。本综述包括八项随机对照试验。结果表明，PDL 治疗在改善整体瘢痕外观方面可能优于传统方法，但当分别评估瘢痕参数时，结果相当。建议进行更多的平行对照试验，采用标准化的治疗和疗效评估方法，以评估长期治疗效果和复发率。
