Namik Kemal University School of Medicine, Department of Ophthalmology, Tekirdag, Turkey.
Curr Eye Res. 2013 Jun;38(6):621-5. doi: 10.3109/02713683.2012.749917. Epub 2012 Dec 18.
To evaluate the tear osmolarity and ocular surface changes in patients with polycystic ovary syndrome (PCOS).
Forty-eight patients with recently diagnosed PCOS and thirty-three control volunteers were enrolled in this prospective, observational study. Ocular surface disease index (OSDI) score was calculated. Tear osmolarity was measured using the TearLab Osmolarity System (Tearlab, San Diego, CA, USA). All subjects also underwent the following ophthalmologic evaluation: Schirmer I test, tear-film breakup time (TBUT), ocular surface flourescein staining, and conjunctival impression cytology.
Mean OSDI score was significantly higher in patients with PCOS than control subjects (P = 0.001). Tear osmolarity was similar in both groups (P = 0.404). There were no significant differences between groups in Schirmer I test results, TBUT, and ocular surface flourescein staining scores (P > 0.05). Compared to control group, a statistically significant squamous metaplasia was observed in temporal bulbar conjunctival impression cytology specimens in PCOS group (P = 0.032).
In patients with recently diagnosed PCOS, tear volume and osmolarity are not affected but, conjunctival morphology may be affected, though on a limited scale.
评估多囊卵巢综合征（PCOS）患者的泪液渗透压和眼表变化。
本前瞻性观察研究纳入了 48 例新近诊断为 PCOS 的患者和 33 名对照志愿者。计算眼表疾病指数（OSDI）评分。使用 TearLab 渗透压系统（Tearlab，圣地亚哥，加利福尼亚州，美国）测量泪液渗透压。所有受试者还接受了以下眼科评估：Schirmer I 试验、泪膜破裂时间（TBUT）、眼表荧光素染色和结膜印迹细胞学检查。
PCOS 患者的平均 OSDI 评分明显高于对照组（P = 0.001）。两组的泪液渗透压相似（P = 0.404）。Schirmer I 试验结果、TBUT 和眼表荧光素染色评分在两组之间无显著差异（P > 0.05）。与对照组相比，PCOS 组颞侧球结膜印迹细胞学标本中观察到鳞状化生，差异有统计学意义（P = 0.032）。
在新近诊断为 PCOS 的患者中，泪液体积和渗透压不受影响，但结膜形态可能受到影响，尽管程度有限。
