de Souza-Júnior José Edvan, Garcia Carlos Alexandre de Amorim, Soares Elvira Maria Mafaldo, Maranhão Técia Maria Oliveira, Lemos Telma Maria Araújo Moura, Azevedo George Dantas
Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil ; Department of Biomedical Sciences, State University of Rio Grande do Norte, Mossoró, RN, Brazil ; Department of Biomedical Sciences, Faculty of Health Sciences, Federal University of Rio Grande do Norte, Central Campus, St. Atirador Miguel Antônio da Silva Neto, s/n, Aeroporto, 59607-360 Mossóro, RN, Brazil.
Department of Surgery, Onofre Lopes University Hospital, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
J Ophthalmol. 2015;2015:193078. doi: 10.1155/2015/193078. Epub 2015 Feb 11.
Objective. To compare macular thickness (MT) and retinal nerve fiber layers (RNFL) between women with polycystic ovary syndrome (PCOS) and healthy women. Materials and Methods. The study included 45 women with PCOS and 47 ovulatory women undergoing clinical-gynecological and ophthalmic evaluations, including measurement of MT, RNFL, and optic disc parameters using optical coherence tomography. Results. The superior RNFL around the optic nerve was significantly thicker in PCOS than in healthy volunteers (P = 0.036). After stratification according to insulin resistance, the temporal inner macula (TIM), the inferior inner macula (IIM), the nasal inner macula (NIM), and the nasal outer macula (NOM) were significantly thicker in PCOS group than in control group (P < 0.05). Both the presence of obesity associated with insulin resistance (P = 0.037) and glucose intolerance (P = 0.001) were associated with significant increase in the PC1 mean score, relative to MT. A significant increase in the PC2 mean score occurred when considering the presence of metabolic syndrome (P < 0.0001). There was a significant interaction between obesity and inflammation in a decreasing mean PC2 score relative to macular RNFL thickness (P = 0.034). Conclusion. Decreased macular RNFL thickness and increased total MT are associated with metabolic abnormalities, while increased RNFL thickness around the optic nerve is associated with hormonal changes inherent in PCOS.
目的。比较多囊卵巢综合征（PCOS）女性与健康女性的黄斑厚度（MT）和视网膜神经纤维层（RNFL）。材料与方法。该研究纳入了45名PCOS女性和47名排卵正常的女性，她们接受了临床妇科和眼科评估，包括使用光学相干断层扫描测量MT、RNFL和视盘参数。结果。PCOS患者视神经周围的上方RNFL明显比健康志愿者厚（P = 0.036）。根据胰岛素抵抗分层后，PCOS组的颞侧黄斑内层（TIM）、下方黄斑内层（IIM）、鼻侧黄斑内层（NIM）和鼻侧黄斑外层（NOM）明显比对照组厚（P < 0.05）。与胰岛素抵抗相关的肥胖（P = 0.037）和葡萄糖不耐受（P = 0.001）的存在，相对于MT，均与PC1平均得分显著增加相关。考虑到代谢综合征的存在时，PC2平均得分显著增加（P < 0.0001）。相对于黄斑RNFL厚度，肥胖与炎症之间存在显著的相互作用，导致平均PC2得分降低（P = 0.034）。结论。黄斑RNFL厚度降低和总MT增加与代谢异常相关，而视神经周围RNFL厚度增加与PCOS固有的激素变化相关。
