Department of Ophthalmology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Obstetrics & Gynaecology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Indian J Ophthalmol. 2022 Oct;70(10):3591-3595. doi: 10.4103/ijo.IJO_36_22.
To compare the optical coherence tomography (OCT)-based retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness at the posterior pole, and total macular thickness of women with the polycystic ovarian syndrome (PCOS) versus healthy reproductive age group females.
The study included 110 eyes of 55 diagnosed cases of PCOS (study group) and 110 eyes of 55 healthy reproductive age group (15-49 years) females (control group). All patients underwent a detailed ophthalmological evaluation followed by an OCT to measure their retinal thicknesses. The body mass index (BMI) of patients was noted and compared with the retinal thickness. Also, the lipid profile and serum testosterone levels of PCOS patients were recorded.
The retinal thicknesses in the two study were similar and there was no statistically significant difference. However, on stratification with BMI, it was seen that in patients with BMI>30 kg/m, the superior Retinal Nerve Fibre Layer (RNFL) was significantly thicker in the PCOS group as compared with the control group (P = 0.0006). The mean serum testosterone level in patients with PCOS was 141.3 ± 23.2. Also, 65.45% of patients had a serum testosterone level of more than 70 ng/dL. The mean HDL cholesterol in patients with PCOS was 38.1 ± 15.6. The mean LDL cholesterol in PCOS patients was 98.4 ± 21.7, and the mean total cholesterol in PCOS patients was 153.6 ± 27.3.
Androgens have a trophic action on nerves, which could explain the increased RNFL thickness in these patients.
比较经光学相干断层扫描（OCT）检测的后极部视网膜神经纤维层（RNFL）和神经节细胞层（GCL）厚度以及整体黄斑厚度在多囊卵巢综合征（PCOS）女性与健康生育年龄组女性中的差异。
本研究纳入了 55 例经诊断患有 PCOS 的女性（研究组，共 110 只眼）和 55 名健康生育年龄组（15-49 岁）女性（对照组，共 110 只眼）。所有患者均接受详细的眼科评估，随后进行 OCT 检查以测量视网膜厚度。记录患者的体重指数（BMI）并与视网膜厚度进行比较。同时，还记录了 PCOS 患者的血脂谱和血清睾酮水平。
两组患者的视网膜厚度相似，无统计学差异。然而，按照 BMI 分层后发现，BMI>30 kg/m²的患者中，PCOS 组的上侧 RNFL 明显比对照组厚（P = 0.0006）。PCOS 患者的平均血清睾酮水平为 141.3 ± 23.2ng/dL。此外，65.45%的患者血清睾酮水平超过 70ng/dL。PCOS 患者的平均 HDL 胆固醇为 38.1 ± 15.6mg/dL。PCOS 患者的 LDL 胆固醇平均为 98.4 ± 21.7mg/dL，总胆固醇平均为 153.6 ± 27.3mg/dL。
雄激素对神经具有营养作用，这可以解释这些患者的 RNFL 厚度增加。
