Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109, USA.
Org Lett. 2013 Jan 4;15(1):46-9. doi: 10.1021/ol303003g. Epub 2012 Dec 18.
A Pd-catalyzed asymmetric alkene 1,2-dioxygenation reaction is described. The diastereoselectivity of the reaction is controlled by tethering a chiral oxime ether directing group to the alkene substrate. The best selectivities are obtained with 8-substituted menthone-derived oxime ether auxiliaries.
Pd 催化的不对称烯丙二氧反应被描述。反应的立体选择性通过将手性肟醚导向基团连接到烯丙基底物上来控制。最好的选择性是通过使用 8 取代的薄荷酮衍生的肟醚助剂获得的。