Ignatova T M, Mukhin N A
Ter Arkh. 2012;84(11):81-8.
The paper presents a detailed review of the data available in the literature on the treatment of cryoglobulinemic vasculitis and some forms of B-cell non-Hodgkin lymphoma caused by hepatitis C virus. It shows treatment successes associated with the use of current combined antiviral therapy (interferon-alpha and ribavirin) and its combination with anti-CD20 monoclonal antibodies (rituximab). The combined therapy with rituximab and antiviral drugs allows a radical improvement of prognosis in nearly 50% of patients. Remaining treatment problems and new drug prospects are discussed.
本文对文献中关于丙型肝炎病毒所致冷球蛋白血症性血管炎及某些形式的B细胞非霍奇金淋巴瘤的治疗数据进行了详细综述。文中展示了使用当前联合抗病毒疗法（α干扰素和利巴韦林）及其与抗CD20单克隆抗体（利妥昔单抗）联合应用所取得的治疗成功案例。利妥昔单抗与抗病毒药物的联合疗法可使近50%的患者预后得到根本性改善。文中还讨论了尚存的治疗问题及新药前景。
