Gordovskaia N B, Kozlovskaia L V, Milovanova S Iu, Ignatova T M, Korotchaeva Iu V
Ter Arkh. 2013;85(6):78-84.
The paper considers the specific features of renal involvement developing in chronic infection caused by hepatitis C virus (HCV) and the current possibilities of treatment. It details the clinical and morphological manifestations of HCV-related cryoglobulinemic glomerulonephritis, and criteria for its diagnosis and prognosis. The author discuss new approaches to treating (severe cryoglobulinemic vasculitis with renal involvement in particular)--antiviral therapy (pegylated interferon-alpha/ribavirin) in combination with biological agents (anti-CD monoclonal antibodies, such as rituximab) to achieve clinical, virological, immunological remissions and a response at a molecular level--to eliminate oligo- and monoclonal B lymphocyte proliferation.
本文探讨了丙型肝炎病毒（HCV）慢性感染所致肾脏受累的具体特征以及当前的治疗可能性。详细阐述了HCV相关冷球蛋白血症性肾小球肾炎的临床和形态学表现及其诊断和预后标准。作者讨论了治疗（尤其是伴有肾脏受累的严重冷球蛋白血症性血管炎）的新方法——抗病毒治疗（聚乙二醇化干扰素-α/利巴韦林）联合生物制剂（抗CD单克隆抗体，如利妥昔单抗），以实现临床、病毒学、免疫学缓解以及分子水平的反应——消除寡克隆和单克隆B淋巴细胞增殖。
