幽门螺杆菌感染对胃癌 MUC5AC 蛋白表达的影响。
Effects of Helicobacter pylori infection on MUC5AC protein expression in gastric cancer.
机构信息
Department of Gastroenterology, The First People's Hospital of Yuhang District, Hangzhou 311100, Zhejiang Province, China.
出版信息
Future Oncol. 2013 Jan;9(1):115-20. doi: 10.2217/fon.12.172.
AIM
To investigate the effects of the expression of the MUC5AC protein in gastric cancer depending on the Helicobacter pylori (Hp) infection status.
MATERIALS & METHODS: The MUC5AC protein and mRNA were detected using western blot and real-time PCR protocols in gastric cancer tissue and stratified for Hp infection. Gastric mucus membranes near the cancer site serve as the control group.
RESULTS
The expression of MUC5AC protein and mRNA is significantly decreased in gastric cancer tissue (p < 0.05). The decrease was more significant in the Hp-infected group than in the Hp-uninfected group (p < 0.05).
CONCLUSION
The infection of Hp is correlated with a decrease in MUC5AC protein amount in gastric cancer tissue. The current result suggests that there may be a potential necessary link between Hp, MUC5AC and gastric cancer.
目的
研究在幽门螺杆菌（Hp）感染状态下，胃腺癌组织中粘蛋白 5AC（MUC5AC）蛋白的表达变化。
材料与方法
采用免疫印迹和实时 PCR 技术检测胃腺癌组织中 MUC5AC 蛋白和 mRNA 的表达情况，并对 Hp 感染进行分层。以癌灶附近的胃黏膜作为对照组。
结果
胃腺癌组织中 MUC5AC 蛋白和 mRNA 的表达显著降低（p＜0.05）。Hp 感染组的降低程度明显大于 Hp 未感染组（p＜0.05）。
结论
Hp 感染与胃腺癌组织中 MUC5AC 蛋白含量减少有关。这一结果提示 Hp、MUC5AC 和胃癌之间可能存在潜在的必然联系。
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