Yamashita T, Hirayama A, Obara T, Fujimoto Y, Kodama T, Kenmotsu M, Okuda A
Dept. of Endocrine Surgery, Tokyo Women's Medical College.
Gan No Rinsho. 1990 Apr;36(5):569-73.
A flow cytometric DNA analysis of papillary thyroid carcinomas has been performed on paraffin-embedded specimens, in order to determine the clinical usefulness of this method by defining the degree of the biological malignancy. Fifty-eight patients with papillary carcinomas were followed from 2 to 8 years. They were classified according to their prognosis into three groups: non-recurrent (47 patients), recurrent (5 patients), and a deceased group (6 patients). Aneuploidy was found in 6 (10.3%) of the total 58 patients. It was more frequently detected in the recurrent (40%) and in the deceased (33.3%) groups than in the non-recurrent group (4.3%). Higher proliferating index values were observed in the deceased group than in the recurrent and non-recurrent groups. These results indicate that a DNA analysis, using routine paraffin-embedded materials, is a useful adjunct in the determination of the degree of the biological malignancy of a papillary carcinoma.
为了通过确定生物学恶性程度来评估流式细胞术DNA分析在甲状腺乳头状癌中的临床应用价值，我们对石蜡包埋标本进行了此项分析。58例乳头状癌患者随访了2至8年。根据预后将他们分为三组：无复发组（47例）、复发组（5例）和死亡组（6例）。58例患者中共有6例（10.3%）检测到非整倍体。复发组（40%）和死亡组（33.3%）的非整倍体检出率高于无复发组（4.3%）。死亡组的增殖指数值高于复发组和无复发组。这些结果表明，使用常规石蜡包埋材料进行DNA分析，有助于确定甲状腺乳头状癌的生物学恶性程度。
