Department of Medical Statistics & Epidemiology, Hamad Medical Corporation, Hamad General Hospital, Doha, Qatar.
Int J Rheum Dis. 2012 Dec;15(6):554-61. doi: 10.1111/1756-185x.12017. Epub 2012 Dec 7.
Epidemiological studies suggest an association between vitamin D and calcium intake and breast cancer. The aim of this study was to determine the association of breast cancer with vitamin D deficiency and osteoporosis according to menopausal status and to examine vitamin D and bone mineral density (BMD) levels in breast cancer patients.
This was an observational cohort hospital-based study. It included 635 patients with breast cancer. Socio-demographic information, type of consanguinity, menopause status, medical history, lifestyle habits, dietary intake, BMD measurements and vitamin D levels were collected. Descriptive and univariate analyses were performed.
Of the studied patients, 36.1% were Qataris, 63.9% non-Qatari Arabs, 40% premenopausal women, 20.9% university graduates and 37.2% housewives. Overall, 31.8% of breast cancer women were affected with osteopenia/osteoporosis. Vitamin D deficiency (10.7% vs. 7.9%) and severe vitamin D insufficiency (39.2% vs. 32.5%) were higher in postmenopausal women than premenopausal women (P < 0.001). Low physical activity (< 30 min/day) was observed among vitamin D deficient (46.8%) and osteoporotic (45%) women. Dietary intake of vitamin D was significantly lower in vitamin D deficient women; these included dairy products (33.1%), milk (38.6%), seafood (39.6%), (P < 0.001) and for osteoporotic women, dairy products (46%), calcium (21.3%), milk (36.1%), yoghurt (37.6%), cheese (37.6%) and sea food (34.7%) (P < 0.001).
The present study findings revealed a high prevalence of vitamin D deficiency and osteoporosis in breast cancer patients. Also, the dietary intake of vitamin D and calcium was significantly lower in breast cancer women.
流行病学研究表明，维生素 D 和钙的摄入与乳腺癌之间存在关联。本研究旨在根据绝经状态确定乳腺癌与维生素 D 缺乏和骨质疏松症的关系，并检查乳腺癌患者的维生素 D 和骨密度（BMD）水平。
这是一项基于医院的观察性队列研究。它包括 635 名乳腺癌患者。收集了社会人口统计学信息、血缘关系类型、绝经状态、病史、生活方式习惯、饮食摄入、BMD 测量和维生素 D 水平。进行了描述性和单变量分析。
在所研究的患者中，36.1%是卡塔尔人，63.9%是非卡塔尔阿拉伯人，40%是绝经前妇女，20.9%是大学毕业生，37.2%是家庭主妇。总体而言，31.8%的乳腺癌女性患有骨质疏松症/骨质疏松症。绝经后妇女的维生素 D 缺乏症（10.7%比 7.9%）和严重维生素 D 不足（39.2%比 32.5%）高于绝经前妇女（P<0.001）。低体力活动（<30 分钟/天）在维生素 D 缺乏症（46.8%）和骨质疏松症（45%）女性中较为常见。维生素 D 缺乏症女性的维生素 D 饮食摄入量明显较低；这些食物包括乳制品（33.1%）、牛奶（38.6%）、海鲜（39.6%）（P<0.001），对于骨质疏松症女性，乳制品（46%）、钙（21.3%）、牛奶（36.1%）、酸奶（37.6%）、奶酪（37.6%）和海鲜（34.7%）（P<0.001）。
本研究结果显示，乳腺癌患者中维生素 D 缺乏症和骨质疏松症的患病率很高。此外，乳腺癌女性的维生素 D 和钙的饮食摄入量明显较低。
