Department of Psychology, University of Canterbury, Private Bag 4800, Christchurch, New Zealand.
Expert Rev Neurother. 2013 Jan;13(1):49-73. doi: 10.1586/ern.12.143.
Ingesting minerals and vitamins in combination makes physiological sense, and research on the use of broad-spectrum formulations for psychiatric symptoms is increasing rapidly. This review covers formulas consisting of at least four vitamins and/or minerals and includes four experimental designs: randomized controlled trials, open-label trials, case-control studies and case studies with within-subject crossovers. Nevertheless, there is evidence for the efficacy of micronutrients in the treatment of stress and antisocial behaviors as well as depressed mood in nonclinical and elderly populations. Many reports studied mood changes in healthy populations, making it difficult to generalize to clinical samples. There is also preliminary support for the treatment of autism with micronutrients. However, despite positive preliminary findings, there are less data available to support efficacy of micronutrient formulas in treating bipolar disorder, attention deficit-hyperactivity disorder and substance abuse/dependence and no clinical trials have been done with clinically depressed or anxious patient samples, psychosis or eating disorders.
摄入矿物质和维生素的组合具有生理学意义，并且针对精神症状使用广谱配方的研究正在迅速增加。本综述涵盖了至少包含四种维生素和/或矿物质的配方，并包括四种实验设计：随机对照试验、开放标签试验、病例对照研究和具有个体内交叉的病例研究。尽管如此，仍有证据表明微量营养素在治疗压力和反社会行为以及非临床和老年人群中的抑郁情绪方面具有疗效。许多报告研究了健康人群的情绪变化，因此很难推广到临床样本。微量营养素也初步支持自闭症的治疗。然而，尽管有初步的积极发现，但在治疗双相情感障碍、注意缺陷多动障碍和物质滥用/依赖方面，可用的数据支持微量营养素配方的疗效较少，并且没有针对临床抑郁或焦虑患者样本、精神病或饮食失调进行临床试验。
