Department of Haematology/Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Pediatr Blood Cancer. 2013 Jun;60(6):1027-30. doi: 10.1002/pbc.24426. Epub 2012 Dec 19.
In cancer control research, the objective is to reduce overall morbidity and mortality by decreasing acute and delayed treatment-related toxicities in all children with cancer. To date, the Children's Oncology Group (COG) has focused on infection, neurocognition, quality of life (QoL), and nutrition/antiemetics. COG is conducting randomized controlled trials (RCTs) to determine prophylaxis strategies that will reduce infections in high-risk populations. Two RCTs are determining if modafinil or computerized cognitive training improve cognitive functioning in pediatric brain tumor patients. QoL is being assessed in acute leukemia patients. Improved supportive care outcomes will only occur when the most effective interventions are established.
在癌症控制研究中，目标是通过降低所有癌症儿童的急性和延迟治疗相关毒性，来降低整体发病率和死亡率。迄今为止，儿童肿瘤学组（COG）专注于感染、神经认知、生活质量（QoL）和营养/止吐药。COG正在进行随机对照试验（RCT），以确定预防策略，以减少高危人群的感染。两项 RCT 正在确定莫达非尼或计算机认知训练是否能改善脑肿瘤患儿的认知功能。急性白血病患者的 QoL 正在评估中。只有当确定了最有效的干预措施时，才能改善支持性护理的结果。
