Learning and Research Institute, Barretos Cancer Hospital, Barretos, Brazil.
Department of Clinical Oncology, Barretos Cancer Hospital, Barretos, Brazil.
BMJ Open. 2020 May 5;10(5):e035844. doi: 10.1136/bmjopen-2019-035844.
To identify the association of multiple symptoms and clinical characteristics on quality of life (QoL) of paediatric patients with cancer.
A descriptive, cross-sectional study.
South American Children's Hospital for Cancer Treatment (Barretos, São Paulo, Brazil).
A total of 157 participants, 116 paediatric patients, diagnosed with cancer, undergoing chemotherapy treatment, between 7 and 18 years of age and 41 proxies for patients between 2 and 6 years of age.
The severity and prevalence ofsymptoms were identified through the use of a culturally adapted multi-symptomscreening tool, and the influence these symptoms, in association with clinicalcharacteristics, had on the QOL of Brazilian pediatric cancer patients wasassessed.
Prevalent symptoms identified by all participants were 'feeling tired' (98, 62.4%), 'feeling more or less hungry (do not feel like eating) than you usually do' (96, 61.1%), 'changes in taste (flavour of the food)' (89, 56.7%), 'throwing up or feeling like you may throw up' (77, 49%) and 'changes in how your body (visually) or face looks' (72, 45.9%). The multivariate analysis for symptom severity as reported by proxies showed that surgery (OR 0.20, 95% CI 0.04 to 0.98, p=0.047) and time of diagnosis (OR 0.14, 95% CI 0.03 to 0.66, p=0.012) were associated with a decreased OR of high severity symptoms.An analysis of the clinical characteristics associated with Pediatric Quality of Life Inventory (PedsQL) demonstrated no significant effect on QoL in any of the domains evaluated. The association between Symptom Screening in Pediatrics Tool and PedsQL in the self-report version demonstrated a significant negative influence of all symptoms on the QoL.
The prevalence of symptoms experienced among pediatric patients during treatment was high and significantly influenced all aspects of quality of life,especially in the emotional domain.
确定多种症状和临床特征与癌症患儿生活质量（QoL）的关系。
描述性、横断面研究。
南美儿童癌症治疗医院（巴西巴雷图斯）。
共有 157 名参与者，其中 116 名儿科患者被诊断患有癌症，正在接受化疗，年龄在 7 至 18 岁之间，41 名患者的代理人年龄在 2 至 6 岁之间。
使用文化适应的多症状筛查工具确定症状的严重程度和患病率，评估这些症状与临床特征的相关性对巴西儿科癌症患者 QoL 的影响。
所有参与者均出现的常见症状包括“感到疲倦”（98 例，62.4%）、“感觉比平时更饿（不想吃饭）”（96 例，61.1%）、“味觉变化（食物味道）”（89 例，56.7%）、“呕吐或感觉可能会呕吐”（77 例，49%）和“身体（外观）或面部外观变化”（72 例，45.9%）。代理人报告的症状严重程度的多变量分析显示，手术（OR 0.20，95%CI 0.04 至 0.98，p=0.047）和诊断时间（OR 0.14，95%CI 0.03 至 0.66，p=0.012）与高严重度症状的降低 OR 相关。分析与儿科生存质量指数（PedsQL）相关的临床特征显示，在评估的任何领域，QoL 均无显著影响。症状筛查儿科工具与自我报告版本的 PedsQL 之间的关联表明，所有症状对 QoL 均有显著负面影响。
治疗期间儿科患者经历的症状发生率较高，对生活质量的各个方面都有显著影响，尤其是在情绪领域。
