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肝脏核因子与大鼠磷酸烯醇式丙酮酸羧激酶启动子的发育调控相互作用。

Developmentally regulated interactions of liver nuclear factors with the rat phosphoenolpyruvate carboxykinase promoter.

作者信息

Trus M, Benvenisty N, Cohen H, Reshef L

机构信息

Department of Developmental Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

出版信息

Mol Cell Biol. 1990 May;10(5):2418-22. doi: 10.1128/mcb.10.5.2418-2422.1990.

DOI:10.1128/mcb.10.5.2418-2422.1990
PMID:2325658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC360591/
Abstract

A sequential pattern of interactions of trans-acting factors in rat liver with the phosphoenolpyruvate carboxykinase promoter during late development was observed. A liver-enriched factor, possibly AF1, interacted with the promoter in fetal liver, whereas a factor with the characteristics of C/EBP bound the promoter after birth with the onset of the gene expression.

摘要

在大鼠肝脏发育后期，观察到反式作用因子与磷酸烯醇丙酮酸羧激酶启动子的相互作用存在一种顺序模式。一种肝脏富集因子，可能是AF1，在胎儿肝脏中与启动子相互作用，而具有C/EBP特征的因子在出生后随着基因表达的开始与启动子结合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/af9f9dcc3fba/molcellb00041-0593-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/4831a8a111ee/molcellb00041-0590-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/5d7729e1a76c/molcellb00041-0591-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/96c490f95318/molcellb00041-0592-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/c3d1261d0e10/molcellb00041-0593-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/af9f9dcc3fba/molcellb00041-0593-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/4831a8a111ee/molcellb00041-0590-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/5d7729e1a76c/molcellb00041-0591-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/96c490f95318/molcellb00041-0592-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/c3d1261d0e10/molcellb00041-0593-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12db/360591/af9f9dcc3fba/molcellb00041-0593-b.jpg

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Phosphoenolpyruvate carboxykinase and pyruvate carboxylase in developing rat liver.发育中大鼠肝脏中的磷酸烯醇式丙酮酸羧激酶和丙酮酸羧化酶
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Functional and physical associations between NF-kappa B and C/EBP family members: a Rel domain-bZIP interaction.NF-κB与C/EBP家族成员之间的功能和物理关联：Rel结构域与碱性亮氨酸拉链的相互作用
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Mol Cell Biol. 1994 Nov;14(11):7124-33. doi: 10.1128/mcb.14.11.7124-7133.1994.
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The interplay of ubiquitous DNA-binding factors, availability of binding sites in the chromatin, and DNA methylation in the differential regulation of phosphoenolpyruvate carboxykinase gene expression.
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Differential regulation of the rat phosphoenolpyruvate carboxykinase gene expression in several tissues of transgenic mice.转基因小鼠多个组织中大鼠磷酸烯醇式丙酮酸羧激酶基因表达的差异调控
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来自小鼠白蛋白启动子的组织特异性体外转录。
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The cell-specific enhancer of the mouse transthyretin (prealbumin) gene binds a common factor at one site and a liver-specific factor(s) at two other sites.小鼠甲状腺素运载蛋白（前白蛋白）基因的细胞特异性增强子在一个位点结合一种常见因子，在另外两个位点结合肝脏特异性因子。
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