Department of Medicine, Clinical Immunology and Allergy Unit, Karolinska Institute, Stockholm, Sweden.
Int Arch Allergy Immunol. 2013;161(1):87-90. doi: 10.1159/000345133. Epub 2012 Dec 15.
A reproducible standard for a graded allergen response in allergic rhinitis is lacking. The aim was to evaluate basophil allergen threshold sensitivity, CD-sens, as a diagnostic complement to nasal allergen challenge.
Twenty-six patients with a history of allergic rhinitis due to grass pollen were intranasally challenged and nasal symptom score and peak nasal inspiratory flow (PNIF) changes were determined after 15 min. A 20% decrease in PNIF or a symptom score ≥2 were considered a positive test. A blood sample for CD-sens was drawn before each challenge. Eighteen patients were tested twice.
CD-sens agreed with the positive or negative nasal symptom score in 22/26 and PNIF in 24/26 patients. After the second challenge, 14/18 patients had the same symptom, 17/18 the same PNIF, while all had identical CD-sens classification.
CD-sens appears to be a reproducible test for diagnosis of allergic rhinitis with great advantages also for follow-up of disease development and treatment effects.
变应性鼻炎的变应原反应分级标准仍不明确。本研究旨在评估嗜碱性粒细胞变应原阈值敏感性（CD-sens）作为鼻变应原激发试验的补充诊断方法。
26 例因花粉过敏导致变应性鼻炎的患者接受了鼻内激发试验，激发后 15 分钟测定鼻症状评分和最大鼻吸气峰流速（PNIF）的变化，PNIF 下降 20%或症状评分≥2 被认为是阳性试验。在每次激发前均采集血样进行 CD-sens 检测。其中 18 例患者进行了两次激发试验。
CD-sens 与 26 例患者中的 22 例鼻症状评分和 24 例 PNIF 结果呈阳性或阴性一致。在第二次激发后，18 例患者中的 14 例具有相同的症状，17 例具有相同的 PNIF，而所有患者的 CD-sens 分类均相同。
CD-sens 似乎是一种可重复的过敏性鼻炎诊断测试，对疾病进展和治疗效果的随访也具有很大优势。
