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How do environments talk to genes?

作者信息

Szyf Moshe

机构信息

Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.

出版信息

Nat Neurosci. 2013 Jan;16(1):2-4. doi: 10.1038/nn.3286.

DOI:10.1038/nn.3286
PMID:23257925
Abstract
摘要

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How do environments talk to genes?环境如何与基因进行交流?
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Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.等位基因特异性 FKBP5 DNA 去甲基化介导基因-儿童期创伤的相互作用。
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Allele-specific DNA methylation level of FKBP5 is associated with post-traumatic stress disorder.FKBP5 基因特异性 DNA 甲基化水平与创伤后应激障碍有关。
Psychoneuroendocrinology. 2019 May;103:1-7. doi: 10.1016/j.psyneuen.2018.12.226. Epub 2018 Dec 19.
4
Epigenetics: a new frontier for post-traumatic stress disorder?表观遗传学:创伤后应激障碍的新前沿?
Epigenomics. 2014 Apr;6(2):157-9. doi: 10.2217/epi.14.6.
5
[Posttraumatic stress disorder (PTSD) as a consequence of the interaction between an individual genetic susceptibility, a traumatogenic event and a social context].[创伤后应激障碍(PTSD)作为个体遗传易感性、创伤性事件和社会环境之间相互作用的结果]
Encephale. 2012 Oct;38(5):373-80. doi: 10.1016/j.encep.2011.12.003. Epub 2012 Jan 24.
6
FKBP5 polymorphisms, childhood abuse, and PTSD symptoms: Results from the National Health and Resilience in Veterans Study.FKBP5基因多态性、童年期虐待与创伤后应激障碍症状:退伍军人健康与恢复力全国性研究结果
Psychoneuroendocrinology. 2016 Jul;69:98-105. doi: 10.1016/j.psyneuen.2016.04.001. Epub 2016 Apr 5.
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Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD.FKBP5、儿茶酚-O-甲基转移酶(COMT)和α-5烟碱型乙酰胆碱受体(CHRNA5)基因多态性与创伤后应激障碍(PTSD)门诊高危患者PTSD的相关性
Psychiatry Res. 2011 Jun 30;188(1):173-4. doi: 10.1016/j.psychres.2011.03.002. Epub 2011 Apr 6.
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FKBP5 allele-specific epigenetic modification in gene by environment interaction.基因中FKBP5等位基因特异性表观遗传修饰的基因与环境相互作用
Neuropsychopharmacology. 2015 Jan;40(1):244-6. doi: 10.1038/npp.2014.208.
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FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals.FKBP5 相关 miRNA 特征作为新近创伤个体 PTSD 的潜在生物标志物。
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Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies.利用FKBP5基因多态性定义创伤后应激障碍的生物学不同亚型:来自内分泌和基因表达研究的证据
Arch Gen Psychiatry. 2011 Sep;68(9):901-10. doi: 10.1001/archgenpsychiatry.2011.50. Epub 2011 May 2.

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本文引用的文献

1
Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions.等位基因特异性 FKBP5 DNA 去甲基化介导基因-儿童期创伤的相互作用。
Nat Neurosci. 2013 Jan;16(1):33-41. doi: 10.1038/nn.3275. Epub 2012 Dec 2.
2
Peripheral SLC6A4 DNA methylation is associated with in vivo measures of human brain serotonin synthesis and childhood physical aggression.外周 SLC6A4 基因甲基化与体内人类大脑 5-羟色胺合成和儿童躯体攻击行为的测量指标相关。
PLoS One. 2012;7(6):e39501. doi: 10.1371/journal.pone.0039501. Epub 2012 Jun 20.
3
The early-life social environment and DNA methylation.
应激过度障碍的表观遗传学景观:DNA 甲基化动态的关键作用。
Int Rev Neurobiol. 2021;156:127-183. doi: 10.1016/bs.irn.2020.08.002. Epub 2020 Sep 30.
4
The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder.糖皮质激素受体 - FKBP51复合物与恐惧条件反射和创伤后应激障碍有关。
J Clin Invest. 2020 Feb 3;130(2):877-889. doi: 10.1172/JCI130363.
5
Long-Lasting Effects of Prenatal Ethanol Exposure on Fear Learning and Development of the Amygdala.产前乙醇暴露对恐惧学习及杏仁核发育的长期影响。
Front Behav Neurosci. 2018 Sep 4;12:200. doi: 10.3389/fnbeh.2018.00200. eCollection 2018.
6
An epigenetic pathway approach to investigating associations between prenatal exposure to maternal mood disorder and newborn neurobehavior.采用表观遗传学途径研究产妇心境障碍与新生儿神经行为之间的关系
Dev Psychopathol. 2018 Aug;30(3):881-890. doi: 10.1017/S0954579418000688.
7
Research Review: Intergenerational transmission of disadvantage: epigenetics and parents' childhoods as the first exposure.研究综述:劣势的代际传递:表观遗传学和父母的童年是第一次暴露。
J Child Psychol Psychiatry. 2019 Feb;60(2):119-132. doi: 10.1111/jcpp.12877. Epub 2018 Feb 23.
8
Epigenetic Mechanisms in Developmental Alcohol-Induced Neurobehavioral Deficits.发育性酒精诱导神经行为缺陷中的表观遗传机制
Brain Sci. 2016 Apr 8;6(2):12. doi: 10.3390/brainsci6020012.
9
HPA Axis Gene Expression and DNA Methylation Profiles in Rats Exposed to Early Life Stress, Adult Voluntary Ethanol Drinking and Single Housing.早年生活应激、成年期自愿饮酒和单笼饲养大鼠的下丘脑-垂体-肾上腺(HPA)轴基因表达及DNA甲基化谱
Front Mol Neurosci. 2016 Jan 26;8:90. doi: 10.3389/fnmol.2015.00090. eCollection 2015.
10
Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells.前额叶皮层和外周 T 细胞 DNA 甲基化图谱中慢性疼痛的重叠特征。
Sci Rep. 2016 Jan 28;6:19615. doi: 10.1038/srep19615.
早期生活社会环境与 DNA 甲基化。
Clin Genet. 2012 Apr;81(4):341-9. doi: 10.1111/j.1399-0004.2012.01843.x. Epub 2012 Feb 13.
4
Gene expression and methylation signatures of MAN2C1 are associated with PTSD.MAN2C1 的基因表达和甲基化特征与 PTSD 相关。
Dis Markers. 2011;30(2-3):111-21. doi: 10.3233/DMA-2011-0750.
5
Epigenetic and immune function profiles associated with posttraumatic stress disorder.与创伤后应激障碍相关的表观遗传和免疫功能特征。
Proc Natl Acad Sci U S A. 2010 May 18;107(20):9470-5. doi: 10.1073/pnas.0910794107. Epub 2010 May 3.
6
Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks.暴露于世贸中心袭击事件后与创伤后应激障碍相关的基因表达模式。
Biol Psychiatry. 2009 Oct 1;66(7):708-11. doi: 10.1016/j.biopsych.2009.02.034. Epub 2009 Apr 25.
7
Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.FKBP5基因多态性与童年期虐待经历和成年人创伤后应激障碍症状风险的关联。
JAMA. 2008 Mar 19;299(11):1291-305. doi: 10.1001/jama.299.11.1291.
8
Acetylation-induced transcription is required for active DNA demethylation in methylation-silenced genes.乙酰化诱导的转录对于甲基化沉默基因中的活性DNA去甲基化是必需的。
Mol Cell Biol. 2007 Nov;27(21):7462-74. doi: 10.1128/MCB.01120-07. Epub 2007 Aug 20.
9
Epigenetic programming by maternal behavior.母性行为的表观遗传编程。
Nat Neurosci. 2004 Aug;7(8):847-54. doi: 10.1038/nn1276. Epub 2004 Jun 27.
10
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.生活压力对抑郁症的影响:5-羟色胺转运体(5-HTT)基因多态性的调节作用
Science. 2003 Jul 18;301(5631):386-9. doi: 10.1126/science.1083968.