Service de Neurologie, CHU Besançon, Besançon, France.
Eur Neurol. 2013;69(3):166-70. doi: 10.1159/000345482. Epub 2012 Dec 19.
BACKGROUND/AIMS: Numerous authors have described olfactory dysfunction in multiple sclerosis (MS) in recent years. The aim of this study was to specify the aspects of olfactory perception that are most affected and to identify any correlations with clinical, anatomical and functional data.
50 patients with remitting or secondary progressive MS were included. Personal data were collected (medical history, characteristics of their disease, depression and disability scores and number of lesions on cerebral imaging). An olfactory test (Sniffin Sticks®) was used to evaluate subjects' olfactory function.
The odor detection threshold is the most sensitive marker, with 40% of patients presenting hyposmia. The ability to identify odors is affected later on, and is inversely correlated with the level of disability.
Our results confirm that several aspects of olfactory function are altered in MS, particularly those aspects requiring greater cognitive involvement, such as discrimination and identification of odors.
背景/目的：近年来，许多作者描述了多发性硬化症（MS）中的嗅觉功能障碍。本研究的目的是明确受影响最大的嗅觉感知方面，并确定与临床、解剖和功能数据的任何相关性。
共纳入 50 例缓解期或继发性进展性 MS 患者。收集个人数据（病史、疾病特征、抑郁和残疾评分以及脑影像学上的病变数量）。使用嗅觉测试（Sniffin Sticks®）评估受试者的嗅觉功能。
气味探测阈值是最敏感的标志物，40%的患者表现为嗅觉减退。识别气味的能力较晚受到影响，且与残疾程度呈负相关。
我们的结果证实，MS 中嗅觉功能的几个方面发生改变，特别是那些需要更多认知参与的方面，例如气味的辨别和识别。
