Vijayalakshmi D, Fathima Shabana, Ramakrishnan K, Devi M
Department of Oral & Maxillofacial Pathology, Adhiparasakthi Dental College & Hospital, Tamil Nadu, India.
BMJ Case Rep. 2012 Dec 19;2012:bcr2012007400. doi: 10.1136/bcr-2012-007400.
Malignant fibrous histiocytoma (MFH) is widely regarded as the commonest soft tissue sarcoma of adulthood which tends to occur in the deep soft tissues of the extremities and the retroperitoneum. Uncertain histogenesis and numerous subtypes make MFH a rather controversial entity. These tumours are relatively rare in the head and neck region accounting for only 1-3% of all cases of MFH. MFH exhibits a heterogenous histology of spindle cells in a characteristic storiform pattern with pleomorphic tumour cells and giant cells. A case is reported of an MFH of the gingiva in a 60-year-old woman who presented with a painful swelling originating from the left maxillary gingiva. The clinical, histopathological and immunohistochemical findings are discussed.
恶性纤维组织细胞瘤（MFH）被广泛认为是成人最常见的软组织肉瘤，倾向于发生在四肢深部软组织和腹膜后。组织发生不确定且亚型众多，使得MFH成为一个颇具争议的实体。这些肿瘤在头颈部相对少见，仅占所有MFH病例的1 - 3%。MFH呈现出梭形细胞的异质性组织学特征，具有特征性的车辐状排列，伴有多形性肿瘤细胞和巨细胞。本文报告了一例60岁女性牙龈MFH病例，该患者表现为源于左上颌牙龈的疼痛性肿胀。并对临床、组织病理学和免疫组化结果进行了讨论。
