2型糖尿病中Nlrp3炎性小体的激活：是否具有临床相关性？ - Suppr

Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?

作者信息

Dixit Vishwa Deep

机构信息

Immunobiology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA.

出版信息

Diabetes. 2013 Jan;62(1):22-4. doi: 10.2337/db12-1115.

DOI:10.2337/db12-1115

PMID:23258906

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3526045/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b69/3526045/2b2e70d75075/22fig1.jpg

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本文引用的文献

Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes.2 型糖尿病患者中 NRLP3 炎性小体激活上调。

Diabetes. 2013 Jan;62(1):194-204. doi: 10.2337/db12-0420. Epub 2012 Oct 18.

IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.IRE1α 通过诱导硫氧还蛋白相互作用蛋白激活 NLRP3 炎症小体，在无法挽回的内质网应激下促进程序性细胞死亡。

Cell Metab. 2012 Aug 8;16(2):250-64. doi: 10.1016/j.cmet.2012.07.007.

High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction.高脂饮食会引发脂肪组织中 SIRT1 的炎症诱导性切割，从而促进代谢功能障碍。

Cell Metab. 2012 Aug 8;16(2):180-8. doi: 10.1016/j.cmet.2012.07.003.

Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.中性粒细胞通过分泌弹性蛋白酶介导高脂饮食喂养的小鼠胰岛素抵抗。

Nat Med. 2012 Sep;18(9):1407-12. doi: 10.1038/nm.2885.

Immunological complications of obesity.肥胖的免疫并发症。

Nat Immunol. 2012 Jul 19;13(8):707-12. doi: 10.1038/ni.2343.

Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans.NLRP3 炎性体和 T 细胞群体标志物在脂肪组织中的表达与人的胰岛素抵抗和葡萄糖代谢受损有关。

Mol Immunol. 2012 Mar;50(3):142-9. doi: 10.1016/j.molimm.2012.01.005. Epub 2012 Feb 8.

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Inflammasome is a central player in the induction of obesity and insulin resistance.炎症小体是诱导肥胖和胰岛素抵抗的核心因素。

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Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage.消除 NLRP3-ASC 炎症小体可预防慢性肥胖诱导的胰腺损伤。

Endocrinology. 2011 Nov;152(11):4039-45. doi: 10.1210/en.2011-1326. Epub 2011 Aug 23.

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Nlrp3 inflammasome activation in type 2 diabetes: is it clinically relevant?

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