Division of Cardiology, Department of Medical Specialties, Geneva University Hospitals and University of Geneva, 4 Rue Gabrielle Perret-Gentil, 1211 Geneva, Switzerland.
Mediators Inflamm. 2012;2012:243158. doi: 10.1155/2012/243158. Epub 2012 Nov 7.
We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease. 48 nonobese and 43 obese subjects were included. CAC score was measured by thorax scanner and defined by an Agatston score > 0. Coronary endothelial dysfunction was determined by measuring myocardial blood flow responses to cold pressor test (CPT) on PET/CT. Serum anti-apoA-1 IgG levels were measured by ELISA. Prevalence of coronary calcification was similar between the two study groups, but the prevalence of coronary endothelial dysfunction was higher in obese subjects. Anti-apoA-1 IgG levels and positivity rate were higher in obese than in nonobese individuals. CAC score was higher in anti-apoA-1 IgG positive subjects. ROC analyses indicated that anti-apoA-1 IgG levels were significant predictors of CAC > 0, but not of coronary endothelial dysfunction with a negative predictive value of 94%. Anti-apoA-1 IgG positivity was associated with a 17-fold independent increased risk of CAC > 0. In conclusion, those preliminary results indicate that anti-apoA-1 IgG autoantibodies are raised in obese subjects and independently predict the presence of coronary calcification in this population but not the presence of coronary endothelial dysfunction.
我们旨在确定抗载脂蛋白（apo）A-1 IgG 水平是否可作为肥胖和非肥胖、无心血管疾病患者冠状动脉钙化（CAC）和冠状动脉内皮功能障碍的独立预测因子。纳入了 48 名非肥胖者和 43 名肥胖者。通过胸部扫描仪测量 CAC 评分，并通过 Agatston 评分>0 进行定义。通过 PET/CT 测量冷加压试验（CPT）时的心肌血流反应来确定冠状动脉内皮功能障碍。通过 ELISA 测量血清抗 apoA-1 IgG 水平。两组研究对象的 CAC 发生率相似，但肥胖组的冠状动脉内皮功能障碍发生率更高。肥胖者的抗 apoA-1 IgG 水平和阳性率高于非肥胖者。抗 apoA-1 IgG 阳性者的 CAC 评分更高。ROC 分析表明，抗 apoA-1 IgG 水平是 CAC>0 的显著预测因子，但不是冠状动脉内皮功能障碍的预测因子，其阴性预测值为 94%。抗 apoA-1 IgG 阳性与 CAC>0 的独立风险增加 17 倍相关。总之，这些初步结果表明，肥胖者体内会出现抗 apoA-1 IgG 自身抗体，并且可独立预测该人群 CAC 的存在，但不能预测冠状动脉内皮功能障碍的存在。
