Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia.
Evid Based Complement Alternat Med. 2012;2012:829401. doi: 10.1155/2012/829401. Epub 2012 Nov 27.
Hepato- and nephrotoxicity of Khat consumption (Catha edulis Forskal) have been evoked. Therefore, this study was conducted to evaluate such possible hepatorenal toxicity in female and male Sprague-Dawley rats (SD rats) focusing primarily on liver and kidney. In addition, female and male rats were investigated separately. Accordingly, forty-eight SD-rats (100-120 g) were distributed randomly into four groups of males and female (n = 12). Normal controls (NCs) received distilled water, whereas test groups received 500 mg/kg (low dose (LD)), 1000 mg/kg (medium dose (MD)), or 2000 mg/kg (high dose (HD)) of crude extract of Catha edulis orally for 4 weeks. Then, physical, biochemical, hematological, and histological parameters were analyzed. Results in Khat-fed rats showed hepatic enlargement, abnormal findings in serum aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of male and female SD-rats and serum albumin (A) and serum creatinine (Cr) of female as compared to controls. In addition, histopathological abnormalities confirmed hepatic and renal toxicities of Khat that were related to heavy Khat consumption. In summary, Khat could be associated with hepatic hypertrophy and hepatotoxicity in male and female SD-rats and nephrotoxicity only in female SD-rats.
曾有报道称阿拉伯茶（Catha edulis Forskal）的使用会导致肝毒性和肾毒性。因此，本研究旨在评估雌性和雄性斯普拉格-道利（Sprague-Dawley）大鼠（SD 大鼠）中这种可能的肝肾功能毒性，主要关注肝脏和肾脏。此外，还分别对雌性和雄性大鼠进行了研究。
为此，将 48 只 SD 大鼠（100-120g）随机分为雄性和雌性（n=12）四组。正常对照组（NC）给予蒸馏水，而实验组给予 500mg/kg（低剂量（LD））、1000mg/kg（中剂量（MD））或 2000mg/kg（高剂量（HD））的阿拉伯茶粗提取物，连续口服 4 周。然后，分析了物理、生化、血液学和组织学参数。
结果表明，与对照组相比，阿拉伯茶喂养的大鼠肝脏肿大，雄性和雌性 SD 大鼠血清天冬氨酸氨基转移酶（AST）和碱性磷酸酶（ALP）异常，雌性大鼠血清白蛋白（A）和血清肌酐（Cr）异常。此外，组织病理学异常证实了阿拉伯茶的肝毒性和肾毒性，这与大量食用阿拉伯茶有关。
总之，阿拉伯茶可能与雄性和雌性 SD 大鼠的肝肥大和肝毒性以及雌性 SD 大鼠的肾毒性有关。
