口服恰特草后颌下唾液腺的定性超微结构分析：体内研究。
Qualitative ultrastructural analysis of the submandibular salivary glands after administration of khat: in vivo study.
机构信息
Department of Basic Dental Sciences, Faculty of Dentistry, University of Science and Technology, Taiz, Yemen.
Department of Oral Biology, Faculty of Dentistry, Cairo University, Cairo, 11553, Egypt.
出版信息
BMC Res Notes. 2021 May 13;14(1):180. doi: 10.1186/s13104-021-05595-8.
OBJECTIVE
Khat (Catha edulis Forssk) plant has been widely chewed for its psychostimulatory effects in the African and Arabian Peninsula, particularly in Yemen. Considering the khat leaves are gradually chewed without swallowing, while its active constituents are extracted into saliva, studying the effect of khat on salivary glands is necessary. This work is an extension of the previously published work that studied the effect of khat extract on the rats' submandibular salivary glands in terms of histological and immunohistochemical evaluations. The current research note aimed to better understand this effect on the ultrastructure of submandibular salivary gland cells by using transmission electron microscope.
RESULTS
Oral administration of khat extract produced degenerative changes in the secretory and ductal cells of rats' submandibular salivary glands. These changes involved irregular boundaries of variable sized-nuclei, dilated RER, cytoplasmic vacuoles as well as swollen and degenerated mitochondria.
目的
阿拉伯茶（Catha edulis Forssk）植物因其具有的精神兴奋作用而在非洲和阿拉伯半岛被广泛咀嚼，尤其是在也门。考虑到阿拉伯茶叶子是逐渐咀嚼而不吞咽的，其活性成分被提取到唾液中，因此有必要研究阿拉伯茶对唾液腺的影响。这项工作是之前研究阿拉伯茶提取物对大鼠下颌下唾液腺的组织学和免疫组织化学评估的扩展。本研究报告旨在通过透射电子显微镜更好地了解其对下颌下唾液腺细胞超微结构的影响。
结果
阿拉伯茶提取物的口服给药导致大鼠下颌下唾液腺的分泌细胞和导管细胞发生退行性变化。这些变化涉及大小不一的细胞核不规则边界、扩张的 RER、细胞质空泡以及肿胀和退化的线粒体。
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