Key Laboratory of Plant Nutrition and Fertilizer in South Region, Ministry of Agriculture, Institute of Agricultural Resources and Environment, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, People's Republic of China.
J Agric Food Chem. 2013 Jan 16;61(2):320-4. doi: 10.1021/jf3045022. Epub 2013 Jan 7.
Organoarsenics are widely used as excellent feed additives in animal production in the world. Roxarsone (ROX) and arsanilic acid (ASA) are two organoarsenics permitted to be used in China. We collected 146 animal feed samples to investigate the appearance of ROX, ASA, and potential metabolites, including 3-amino-4-hydroxyphenylarsonic acid (3-A-HPA), 4-hydroxyphenylarsonic acid (4-HPA), As(V), As(III), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in feeds. The stability of ROX in both ROX additives and animal feeds was also examined. The results show that 25.4% of the 146 animal feeds contained organoarsenics, with average contents of ROX and ASA as 7.0 and 21.2 mg of As/kg, respectively. Unexpectedly, As(III) and MMA frequently occurred as As impurities in feeds bearing organoarsenics, with higher contents than organoarsenics in some samples. 3-A-HPA, 4-HPA, and DMA were not detected in all samples. ROX and As impurities in both ROX additives and feeds stayed unchanged in the shelf life. It suggests that As impurities in animal feeds bearing organoarsenics should generate from the use of organoarsenics containing As impurities. This constitutes the first report of As impurities in organoarsenics.
有机胂化合物在世界范围内广泛用作动物生产中的优良饲料添加剂。洛克沙胂（ROX）和阿散酸（ASA）是中国允许使用的两种有机胂化合物。我们收集了 146 个动物饲料样本，以调查 ROX、ASA 和潜在代谢物（包括 3-氨基-4-羟基苯胂酸（3-A-HPA）、4-羟基苯胂酸（4-HPA）、As(V)、As(III)、单甲基胂酸（MMA）和二甲基胂酸（DMA）在饲料中的存在情况。还检查了 ROX 在 ROX 添加剂和动物饲料中的稳定性。结果表明，146 个动物饲料中有 25.4%含有有机胂化合物，ROX 和 ASA 的平均含量分别为 7.0 和 21.2mg As/kg。出人意料的是，在含有有机胂化合物的饲料中，As(III)和 MMA 经常作为 As 杂质出现，在一些样品中的含量高于有机胂化合物。在所有样品中均未检测到 3-A-HPA、4-HPA 和 DMA。ROX 和 ROX 添加剂及饲料中的 As 杂质在保质期内保持不变。这表明，含有有机胂化合物的动物饲料中的 As 杂质应来自含 As 杂质的有机胂化合物的使用。这是首次报道有机胂化合物中的 As 杂质。
