Regenerative Medicine, Institute of Inflammation & Repair, University of Manchester, Manchester, UK.
Regen Med. 2013 Jan;8(1):75-87. doi: 10.2217/rme.12.108.
Low back pain is a leading cause of morbidity in developed societies and is strongly linked to degeneration of the intervertebral disc. The central nucleus pulposus (NP) region is most severely affected during disc degeneration and, consequently, is a focus for novel cell-based regenerative strategies. However, in order to develop such techniques, it is essential to first understand the biology and phenotype of the NP cells intended for repair. Microarray studies have highlighted novel NP markers that will allow a more accurate identification of cells for implantation, and along with other studies, have also revealed the potential importance of a developmental or immature NP cell phenotype in disseminating the optimal cell type for use. Additionally, the degenerative intervertebral disc is a harsh native environment and the effects of this on cells intended for implantation have yet to be fully elucidated; this is crucial for clinical translation of tissue engineered cell-based therapies.
下背痛是发达社会发病率的主要原因，与椎间盘退变密切相关。在椎间盘退变过程中，中央核髓区（NP）受到的影响最为严重，因此成为了新型基于细胞的再生策略的重点。然而，为了开发此类技术，首先了解用于修复的 NP 细胞的生物学和表型是至关重要的。微阵列研究强调了新的 NP 标志物，这将有助于更准确地鉴定用于植入的细胞，并且与其他研究一起，还揭示了发育或未成熟 NP 细胞表型在传播最佳细胞类型方面的潜在重要性。此外，退变的椎间盘是一个恶劣的天然环境，对于用于植入的细胞的影响尚未完全阐明；这对于组织工程细胞治疗的临床转化至关重要。
