Goldie P, Hellström S, Johansson U
Department of Anatomy, University of Umeå, Sweden.
ORL J Otorhinolaryngol Relat Spec. 1990;52(2):104-12. doi: 10.1159/000276114.
The vascular leakage and components of middle ear effusion (MEE) were determined and compared in various experimental otitis media models in the rat: purulent otitis media (POM); serous otitis media (SOM); mucoid-like otitis media (MOM); stimulating the external auditory canal with a 14 degrees C airstream and vagotomy. When the Evans blue technique was used, all otitis media models exhibited a significant increase in middle ear vessel permeability. The MEEs contained numerous PMNLs, except for animals stimulated with a 14 degrees C airstream, in which the MEE was free of cells. The IgG/SIgA ratio in MEEs indicated that the MEE components are derived from serum in the early phases of fluid accumulation, in these otitis media models. In POM, MEE components appeared to be derived from local synthesis by the middle ear mucosa as well.
在大鼠的各种实验性中耳炎模型中，对中耳积液（MEE）的血管渗漏和成分进行了测定和比较：化脓性中耳炎（POM）；浆液性中耳炎（SOM）；黏液样中耳炎（MOM）；用14℃气流刺激外耳道和迷走神经切断术。当使用伊文思蓝技术时，所有中耳炎模型的中耳血管通透性均显著增加。除了用14℃气流刺激的动物外，MEE中含有大量中性粒细胞，在这些动物中MEE无细胞。MEE中的IgG/SIgA比值表明，在这些中耳炎模型中，积液早期MEE成分来源于血清。在POM中，MEE成分似乎也来源于中耳黏膜的局部合成。
