Paparella M M, Sipilä P, Juhn S K, Jung T T
Laryngoscope. 1985 Apr;95(4):414-20.
The role of the subepithelial space (SES) has not received sufficient attention in assessing pathogenesis, pathology, and therefore, clinical diagnosis and treatment of the various forms of otitis media (OM). Temporal bones from patients with OM were classified as cases of acute purulent (POM), serous (SOM), mucoid or secretory (MOM), or chronic otitis media (COM). Controlled morphometric studies were made of cellular components of the SES, along with studies of the epithelium and middle ear space. Corollary studies of biochemistry, cellular components, and prostaglandins (PGs) were done on fluid from the human middle ear. Middle ear effusions (MEE) from animal models of SOM, MOM, and POM were analyzed biochemically. Findings are surprising in that the SES was more actively involved in all forms of OM than had been thought, especially in MOM and COM. Implications are discussed.
在评估各种形式中耳炎（OM）的发病机制、病理学以及临床诊断和治疗时，上皮下间隙（SES）的作用尚未得到足够重视。将中耳炎患者的颞骨分为急性化脓性中耳炎（POM）、浆液性中耳炎（SOM）、黏液性或分泌性中耳炎（MOM）或慢性中耳炎（COM）病例。对SES的细胞成分进行了对照形态学研究，并对上皮和中耳间隙进行了研究。对人中耳液进行了生物化学、细胞成分和前列腺素（PGs）的相关研究。对SOM、MOM和POM动物模型的中耳积液（MEE）进行了生化分析。研究结果令人惊讶，因为SES在所有形式的中耳炎中比之前认为的更积极地参与其中，尤其是在MOM和COM中。文中讨论了其意义。
