实验性中耳炎中青霉素在血清和中耳积液中的扩散动力学。
The kinetics of penicillin diffusion in serum and middle ear effusions in experimentally induced otitis media.
作者信息
Juhn S K, Edlin J, Jung T T, Giebink G S
出版信息
Arch Otorhinolaryngol. 1986;243(3):183-5. doi: 10.1007/BF00470617.
PMID:3753296
Abstract
The kinetics of penicillin diffusion in serum and middle ear effusions (MEE) was studied in experimentally induced serous otitis media (SOM) and purulent otitis media (POM) after systemic injection of procaine-penicillin G. A higher rate of diffusion of penicillin into the middle ear cavity was found in POM than in SOM. The time to reach peak concentrations in MEE was also shorter in POM. Elimination of penicillin from the middle ear cavity was slower in SOM than in POM.
摘要
在全身注射普鲁卡因青霉素G后，对实验性诱导的浆液性中耳炎（SOM）和化脓性中耳炎（POM）中青霉素在血清和中耳积液（MEE）中的扩散动力学进行了研究。发现青霉素向中耳腔的扩散速率在POM中高于SOM。POM中MEE达到峰值浓度的时间也更短。SOM中青霉素从中耳腔的消除比POM中更慢。
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