Tsanaclis A M, Robert F
Acta Neurol Latinoam. 1976;22(1-4):86-103.
The clinical and pathological features of 24 patients with cerebral emboli complicating 66% of our cases of nonbacterial thrombotic endocarditis (NBTE) associated with carcinoma are reviewed. Twelve patients were admitted for a cerebrovascular accident (CVA) while 4 patients developed a CVA during hospitalization. Transient ischemic attacks preceded the CVA in 3 patients. More often the CVA took the form of a single sudden accident. Cerebral infarcts however were generally multiple and hemorrhagic and varied in size and age. In 4 patients large softenings were directly responsible for death. 8.6% of cerebral embolisms were caused by NBTE and in 10 patients cerebral embolization was the first symptom of a carcinoma. The frequency of NBTE in ovarian carcinoma even in the absence of metastases may motivate a more aggressive approach towards unexplained cerebral embolism.
回顾了24例脑栓塞患者的临床和病理特征，这些患者并发于我们66%的与癌症相关的非细菌性血栓性心内膜炎（NBTE）病例。12例患者因脑血管意外（CVA）入院，4例患者在住院期间发生CVA。3例患者在CVA之前出现短暂性脑缺血发作。CVA更常表现为单次突发事故。然而，脑梗死通常是多发性且出血性的，大小和年龄各异。4例患者因大面积软化直接导致死亡。8.6%的脑栓塞由NBTE引起，10例患者脑栓塞是癌症的首发症状。卵巢癌中NBTE的发生率，即使在无转移的情况下，可能促使对不明原因的脑栓塞采取更积极的治疗方法。
