Kooiker J C, MacLean J M, Sumi S M
Arch Neurol. 1976 Apr;33(4):260-4. doi: 10.1001/archneur.1976.00500040044006.
Two subjects with cerebral embolism were found at autopsy to have marantic (nonbacterial thrombotic) endocarditis (NBTE) and an unsuspected carcinoma. A additional 16 subjects with marantic endocarditis and cancer were found on reviewing the autopsy records of 22 subjects with NBTE. Of these 18 subjects with NBTE and cancer, eight developed a stroke during their illness, in five as the initial manifestation of cancer. Although the association of cancer and marantic endocarditis is generally well recognized, cerebral embolism from this source should be more seriously considered as one of the "remote effects" of cancer on the nervous system.
在尸检中发现两名患有脑栓塞的受试者患有消耗性（非细菌性血栓性）心内膜炎（NBTE）以及未被怀疑的癌症。在查阅了22名患有NBTE的受试者的尸检记录后，又发现了另外16名患有消耗性心内膜炎和癌症的受试者。在这18名患有NBTE和癌症的受试者中，有8人在患病期间发生了中风，其中5人中风是癌症的首发表现。尽管癌症与消耗性心内膜炎之间的关联已得到普遍认可，但源于此的脑栓塞应作为癌症对神经系统的“远隔效应”之一而得到更严肃的考虑。
