Department of Microbiology, Hospital Sant Joan de Déu-University of Barcelona, Esplugues, Barcelona, Spain.
Vaccine. 2013 Feb 4;31(7):1117-22. doi: 10.1016/j.vaccine.2012.12.025. Epub 2012 Dec 21.
Although invasive pneumococcal pneumonia remains responsible for a significant number of child hospitalizations, specific data on hospital resource utilization and related costs are limited.
To assess the cost of hospitalizing children with invasive pneumococcal pneumonia and identify the cost determinants of the disease.
Economic evaluation based on an observational study of all children <18 years of age with culture-proved invasive pneumococcal pneumonia admitted to a referral hospital in Barcelona (Spain) during the period January 2001-December 2011. Analysis included demographic, microbiological, epidemiological and clinical variables.
A total of 135 children were included in the study (median age 3.3 years). PCV13 serotypes were detected in 132 (97.8%) cases. Median hospital cost was €4533 (€4078-5435, 95% CI). Median length of stay was 11.0 days (10.6-13.0 days, 95% CI). Variables significantly associated with increased cost in the multivariate analysis were complicated pneumonia (≥2 and 1 complication) versus non-complicated pneumonia (€4919 and €2822 vs. €1399), performance of surgery versus no surgery (€4849 vs. €1435), intensive care versus no intensive care (€6488 vs. €3862) and identification of non-PCV7 serotypes versus PCV7 serotypes (€4656 vs. €1470).
Invasive pneumococcal pneumonia in children makes substantial demands on hospital health care and financial resources that could be mitigated with universal PCV13 childhood immunization programmes and early management of complications.
尽管侵袭性肺炎球菌性肺炎仍是导致大量儿童住院的原因，但有关医院资源利用和相关成本的具体数据有限。
评估儿童侵袭性肺炎球菌性肺炎住院的成本，并确定疾病的成本决定因素。
这是一项基于观察性研究的经济学评价，研究对象为 2001 年 1 月至 2011 年 12 月期间在巴塞罗那（西班牙）一家转诊医院确诊为侵袭性肺炎球菌性肺炎的所有 <18 岁儿童。分析包括人口统计学、微生物学、流行病学和临床变量。
共有 135 名儿童纳入研究（中位年龄 3.3 岁）。132 例（97.8%）患儿检测到 PCV13 血清型。中位住院费用为 4533 欧元（4078-5435 欧元，95%CI）。中位住院时间为 11.0 天（10.6-13.0 天，95%CI）。多变量分析中与费用增加显著相关的变量包括伴有 2 种或 1 种并发症的复杂型肺炎（4919 欧元和 2822 欧元，vs. 无并发症的肺炎 1399 欧元）、行手术与不行手术（4849 欧元和 1435 欧元）、入住重症监护病房与不住重症监护病房（6488 欧元和 3862 欧元）和鉴定出非 PCV7 血清型与鉴定出 PCV7 血清型（4656 欧元和 1470 欧元）。
儿童侵袭性肺炎球菌性肺炎对医院的医疗保健和财政资源提出了巨大的需求，这一需求可通过普遍实施 PCV13 儿童免疫接种计划和早期并发症管理来减轻。
