Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
ASAIO J. 2013 Jan-Feb;59(1):30-6. doi: 10.1097/MAT.0b013e3182768ba9.
Because of the large number of interaction factors involved, the effects of the intra-aortic balloon pump (IABP) have not been investigated deeply. To enhance its clinical efficiency and to better define indications for use, advanced models are required to test the interaction between the IABP and the cardiovascular system. A patient with mild blood pressure depression and a lowered cardiac output is modeled in a lumped parameter computational model, developed with physiologically representative elements for relevant components of circulation and device. IABP support is applied, and the moments of balloon inflation and deflation are varied around their conventional timing modes. For validation purposes, timing is adapted within acceptable ranges in ten patients undergoing IABP therapy for typical clinical indications. In both model and patients, the IABP induces a diastolic blood pressure augmentation as well as a systolic reduction in afterload. The support capabilities of the IABP benefit the most when the balloon is deflated simultaneously with ventricular contraction, whereas inflation before onset of diastole unconditionally interferes with ejection. The physiologic response makes the model an excellent tool for testing the interaction between the IABP and the cardiovascular system, and how alterations of specific IABP parameters (i.e., timing) affect this coupling.
由于涉及到大量的相互作用因素，主动脉内球囊泵（IABP）的效果尚未被深入研究。为了提高其临床效率，并更好地确定使用指征，需要先进的模型来测试 IABP 与心血管系统之间的相互作用。采用具有生理代表性的循环和设备相关元件的集总参数计算模型，对血压轻度降低和心输出量降低的患者进行建模。应用 IABP 支持，并围绕其传统定时模式改变气球充气和放气的时刻。为了验证目的，根据典型临床指征接受 IABP 治疗的十名患者的可接受范围内调整定时。在模型和患者中，IABP 诱导舒张压增加以及收缩压后负荷降低。当气球与心室收缩同时放气时，IABP 的支持能力最有利，而在舒张期开始前充气则无条件地干扰射血。生理反应使该模型成为测试 IABP 与心血管系统相互作用以及特定 IABP 参数（即定时）变化如何影响这种耦合的绝佳工具。
