Department of Radiology, Changzheng Hospital of the Second Military Medical University, No. 415 Fengyang Road, Shanghai 200003, China.
Eur Radiol. 2013 May;23(5):1234-41. doi: 10.1007/s00330-012-2729-2. Epub 2012 Dec 21.
To compare CT volume analysis with MR perfusion imaging in differentiating smokers with normal pulmonary function (controls) from COPD patients.
Sixty-two COPD patients and 17 controls were included. The total lung volume (TLV), total emphysema volume (TEV) and emphysema index (EI) were quantified by CT. MR perfusion evaluated positive enhancement integral (PEI), maximum slope of increase (MSI), maximum slope of decrease (MSD), signal enhancement ratio (SER) and signal intensity ratio (RSI) of perfusion defects to normal lung.
There were 19 class I, 17 class II, 14 class III and 12 class IV COPD patients. No differences were observed in TLV, TEV and EI between control and class I COPD. The control was different from class II, III and IV COPD in TEV and EI. The control was different from each class of COPD in RSI, MSI, PEI and MSD. Differences were found in RSI between class I and III, I and IV, and II and IV COPD. Amongst controls, MR detected perfusion defects more frequently than CT detected emphysema.
Compared with CT, MR perfusion imaging shows higher potential to distinguish controls from mild COPD and appears more sensitive in identifying abnormalities amongst smokers with normal pulmonary function (controls).
• Detailed information is needed to diagnose chronic obstructive pulmonary disease. • High-resolution CT provides detailed anatomical and quantitative information. • Magnetic resonance imaging is demonstrating increasing potential in pulmonary function imaging. • MR perfusion can distinguish mild COPD patients from controls. • MRI appears more sensitive than CT in identifying early abnormalities amongst controls.
比较 CT 容积分析与 MR 灌注成像在区分吸烟且肺功能正常（对照组）与 COPD 患者中的作用。
纳入 62 例 COPD 患者和 17 例对照组。通过 CT 定量测定全肺容积（TLV）、肺气肿总体积（TEV）和肺气肿指数（EI）。MR 灌注评估阳性增强积分（PEI）、最大斜率增加（MSI）、最大斜率下降（MSD）、灌注缺损信号增强比（SER）和信号强度比（RSI）。
COPD 患者中Ⅰ级 19 例，Ⅱ级 17 例，Ⅲ级 14 例，Ⅳ级 12 例。Ⅰ级 COPD 患者与对照组 TLV、TEV 和 EI 无差异，而对照组与Ⅱ、Ⅲ、Ⅳ级 COPD 患者在 TEV 和 EI 方面有差异。对照组与 COPD 各分级患者的 RSI、MSI、PEI 和 MSD 均有差异。Ⅰ级和Ⅲ级、Ⅰ级和Ⅳ级、Ⅱ级和Ⅳ级 COPD 患者间 RSI 也有差异。对照组中，MR 检测到的灌注缺损比 CT 检测到的肺气肿更频繁。
与 CT 相比，MR 灌注成像在区分对照组与轻度 COPD 方面具有更高的潜力，并且在识别吸烟且肺功能正常（对照组）人群中的异常方面更敏感。
诊断慢性阻塞性肺疾病需要详细的信息。
高分辨率 CT 提供详细的解剖和定量信息。
磁共振成像在肺功能成像方面显示出越来越大的潜力。
MR 灌注可以区分轻度 COPD 患者与对照组。
与 CT 相比，MRI 更敏感地识别对照组中的早期异常。
