Ohno Yoshiharu, Iwasawa Tae, Seo Joom Beom, Koyama Hisanobu, Takahashi Hiroshi, Oh Yeon-Mok, Nishimura Yoshihiro, Sugimura Kazuro
Department of Radiology, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, Hyogo, 650-0017, Japan.
Am J Respir Crit Care Med. 2008 May 15;177(10):1095-102. doi: 10.1164/rccm.200709-1322OC. Epub 2008 Feb 14.
Oxygen-enhanced magnetic resonance imaging (MRI) has been proposed as a useful tool for assessing regional morphological and functional changes in chronic obstructive pulmonary disease (COPD).
To prospectively and directly compare the efficacy of O(2)-enhanced MRI and quantitative computed tomography (CT) for smoking-related pulmonary functional loss assessment and clinical stage classification of smoking-related COPD.
One hundred sixty smokers were classified into four age- and gender-matched groups by using the GOLD criteria for smokers: Smokers without COPD (n = 40), Mild COPD (n = 40), Moderate COPD (n = 40), and Severe or Very Severe COPD (n = 40). All smokers underwent O(2)-enhanced MRI, multidetector-row CT, and pulmonary function test. Mean relative enhancement ratio on O(2)-enhanced MRI and CT-based functional lung volume (FLV) on quantitative CT were calculated. To compare the efficacy of O(2)-enhanced MRI and quantitative CT for pulmonary functional loss assessment, both indexes were correlated with pulmonary functional parameters. To determine the efficacy of two methods for clinical stage classification, the four clinical groups' mean relative enhancement ratio and CT-based FLV were statistically compared.
Correlations of both indexes with pulmonary functional parameters were significant (P < 0.0001). Pulmonary functional parameters and mean relative enhancement ratio for the four clinical groups showed significant differences (P < 0.05). CT-based FLVs of smokers without COPD and mild COPD were significantly different from those for moderate COPD and severe or very severe COPD (P < 0.05).
O(2)-enhanced MRI is effective for pulmonary functional loss assessment and clinical stage classification of smoking-related COPD and quantitative CT.
氧增强磁共振成像（MRI）已被提议作为评估慢性阻塞性肺疾病（COPD）区域形态和功能变化的有用工具。
前瞻性地直接比较氧增强MRI和定量计算机断层扫描（CT）在评估吸烟相关肺功能丧失及吸烟相关COPD临床分期方面的疗效。
根据吸烟者的GOLD标准，将160名吸烟者按年龄和性别匹配分为四组：无COPD的吸烟者（n = 40）、轻度COPD（n = 40）、中度COPD（n = 40）以及重度或极重度COPD（n = 40）。所有吸烟者均接受氧增强MRI、多排CT和肺功能测试。计算氧增强MRI上的平均相对增强率以及定量CT上基于CT的功能性肺容积（FLV）。为比较氧增强MRI和定量CT在评估肺功能丧失方面的疗效，将这两个指标与肺功能参数进行相关性分析。为确定两种方法在临床分期方面的疗效，对四个临床组的平均相对增强率和基于CT的FLV进行统计学比较。
两个指标与肺功能参数的相关性均显著（P < 0.0001）。四个临床组的肺功能参数和平均相对增强率显示出显著差异（P < 0.05）。无COPD和轻度COPD吸烟者基于CT的FLV与中度COPD以及重度或极重度COPD者的FLV有显著差异（P < 0.05）。
氧增强MRI在评估吸烟相关COPD的肺功能丧失及临床分期方面与定量CT同样有效。
