克罗米芬可能是非动脉炎性前部缺血性视神经病变的一个病因。
Cyclofenil as a possible cause of non-arteritic anterior ischaemic optic neuropathy.
作者信息
Clarke Benjamin, Sykakis Evripidis, Parmar Dipak N
机构信息
Department of Ophthalmology, Whipps Cross University Hospital, London, UK.
出版信息
BMJ Case Rep. 2012 Dec 20;2012:bcr2012007825. doi: 10.1136/bcr-2012-007825.
Abstract
A 27-year-old woman receiving the steroid drug cyclofenil as a fertility adjunct, experienced blurred vision 24 h after missing a dose and taking a double dose to 'catch up' with her therapeutic protocol. She was found to have a non-arteritic anterior ischaemic optic neuropathy with a visual hemifield defect and impaired optic nerve function, which has not since shown any recovery. This case highlights the prothrombotic potential for the drug when used above normal dosing range, and is therefore of great guidance for those initiating it as a fertility treatment, or in unlicensed use.
摘要
一名27岁女性将类固醇药物克罗米酚作为辅助生育药物使用，在漏服一剂药物后为“赶上”治疗方案而加倍服药，24小时后出现视力模糊。她被诊断为非动脉炎性前部缺血性视神经病变，伴有视野缺损和视神经功能受损，此后未显示任何恢复迹象。该病例突出了该药物在高于正常剂量范围使用时的促血栓形成潜力，因此对那些开始将其用于生育治疗或非许可使用的人具有重要指导意义。
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