[2%利多卡因从腰段硬膜外腔的全身吸收情况]
[Systemic absorption of 2% lidocaine from the lumbar epidural space].
作者信息
Laguarda Rodrigo M, Sangrador García G, Sánchez Alcaraz A, Botella Miró J, Martínez Durá J V, Herrero Gracia C
机构信息
Servicio de Anestesiología y Reanimación, Hospital Lluís Alcanyis, Xàtiva, Valencia.
出版信息
Rev Esp Anestesiol Reanim. 1990 Jan-Feb;37(1):12-4.
The curves of lidocaine (LDC) plasma levels versus time were evaluated in a group of 16 patients receiving single epidural injections of 2% LDC for each metamer to be anesthesized. LDC absorption from epidural space is fairly rapid (tmax = 17 +/- 4 min and t1/2a = 6.2 +/- 1.7 min). This results in very shape peak plasma levels (2.97 +/- 0.87 micrograms/ml with 2% LDC). The remaining pharmacokinetic parameters were: Ke = 0.0057 +/- 0.0022 min-1 and Vd = 1.5 +/- 0.5 l/kg. In all patients adequate levels for operation were obtained.
对一组16例患者进行了评估，这些患者接受单次硬膜外注射2%利多卡因（LDC）以麻醉每个节段。LDC从硬膜外腔的吸收相当迅速（达峰时间 = 17 ± 4分钟，吸收半衰期 = 6.2 ± 1.7分钟）。这导致血浆水平出现非常明显的峰值（2% LDC时为2.97 ± 0.87微克/毫升）。其余药代动力学参数为：消除速率常数（Ke） = 0.0057 ± 0.0022分钟⁻¹，分布容积（Vd） = 1.5 ± 0.5升/千克。所有患者均获得了足以进行手术的血药浓度。
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