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[用于全脊髓麻醉的利多卡因的药代动力学——颈椎注射与腰椎注射的比较]

[Pharmacokinetics of lidocaine used for total spinal anesthesia--a comparison between cervical and lumbar injection].

作者信息

Matsumoto M, Namiki A, Nagai H, Ichimiya T, Masuda Y, Takahashi T

机构信息

Department of Anesthesiology, Sapporo Medical College.

出版信息

Masui. 1993 Jun;42(6):815-8.

PMID:8320796
Abstract

We studied the effects of site of injection on the serum concentration of lidocaine following total spinal block. Six mg.kg-1 of lidocaine was given into the cervical (n = 11) or lumbar (n = 7) subarachnoid space in 10 patients. The mean maximum serum concentration of lidocaine in the cervical group was found to be significantly greater than that in the lumbar group. Lidocaine given into the cervical subarachnoid space seems to be infiltrated easily into the intracranial space and consequently into the systemic circulation.

摘要

我们研究了全脊髓麻醉后注射部位对利多卡因血清浓度的影响。10例患者蛛网膜下腔分别注射6mg·kg-1利多卡因，其中7例注入颈部（n = 11），7例注入腰部（n = 7）。结果发现颈部组利多卡因的平均最高血清浓度显著高于腰部组。注入颈部蛛网膜下腔的利多卡因似乎更容易渗入颅内间隙，进而进入体循环。

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[Pharmacokinetics of lidocaine used for total spinal anesthesia--a comparison between cervical and lumbar injection].[用于全脊髓麻醉的利多卡因的药代动力学——颈椎注射与腰椎注射的比较]
Masui. 1993 Jun;42(6):815-8.
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Comparison of neural blockade and pharmacokinetics after subarachnoid lidocaine in the rhesus monkey. II: Effects of volume, osmolality, and baricity.恒河猴蛛网膜下腔注射利多卡因后神经阻滞和药代动力学的比较。II：容量、渗透压和比重的影响。
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Lidocaine concentration in cerebrospinal fluid after epidural administration: a comparison between epidural and combined spinal-epidural anesthesia.硬膜外给药后脑脊液中的利多卡因浓度：硬膜外麻醉与腰麻-硬膜外联合麻醉的比较
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引用本文的文献

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Intraoperative total spinal anesthesia as a complication of posterior percutaneous endoscopic cervical discectomy.术中全脊髓麻醉作为后路经皮内镜下颈椎间盘切除术的一种并发症。
Eur Spine J. 2018 Jul;27(Suppl 3):431-435. doi: 10.1007/s00586-017-5424-9. Epub 2017 Dec 23.
2
Accidental total subarachnoid block following local scalp anesthesia.局部头皮麻醉后意外发生全蛛网膜下腔阻滞。
J Anesth. 1996 Mar;10(1):66-8. doi: 10.1007/BF02482072.