从楤木叶中提取的具有细胞毒性的三萜皂苷的研究。
Studies on cytotoxic triterpene saponins from the leaves of Aralia elata.
机构信息
School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
出版信息
Food Chem. 2013 May 1;138(1):208-13. doi: 10.1016/j.foodchem.2012.10.041. Epub 2012 Nov 8.
Aralia elata has long been used as a tonic, anticancer and antidiabetic agent in China and Japan, and is widely consumed as food. Phytochemical investigation of the leaves of A. elata has led to the isolation of four new compounds, 3-O-[β-D-glucopyranosyl(1 → 3)-β-D-glucopyranosyl] echinocystic acid 28-O-β-D-glucopyranosyl ester (congmuyenoside I, 1), 3-O-[β-D-glucopyranosyl(1 → 2)-β-D-glucopyranosyl] hederagenin 28-O-β-D-glucopyranosyl ester (congmuyenoside II, 2), 3-O-{[β-D-glucopyranosyl(1 → 2)]-[β-D-glucopyranosyl(1 → 3)-β-D-glucopyranosyl(1 → 3)]-β-D-glucopyranosyl} echinocystic acid 28-O-β-D-glucopyranosyl ester (congmuyenoside III, 3) and 3-O-β-D-glucopyranosyl caulophyllogenin 28-O-β-D-glucopyranosyl ester (congmuyenoside IV, 4), and eight known triterpene saponins (5-12). The structural determination was accomplished with spectroscopic analysis, in particularly (13)C NMR, 2D NMR and HR-ESI-MS techniques. In addition, compounds 5–10 were found for the first time in the genus Aralia. Compounds 1-12 were tested for their inhibition of the growth of HL60, A549 and DU145 cancer cells. In addition, compound 8 showed significant cytotoxic activities against HL60, A549 and DU145 cancer cells with IC(50) values of 15.62, 11.25 and 7.59 μM, respectively.
多蕊木中的新甾体皂苷成分及其抗肿瘤活性研究
多蕊木在我国和日本一直被用作滋补品、抗癌和抗糖尿病药物，也被广泛作为食物食用。对多蕊木叶片的植物化学研究导致了四个新化合物的分离，分别是 3-O-[β-D-吡喃葡萄糖基(1→3)-β-D-吡喃葡萄糖基]羽扇豆醇 28-O-β-D-吡喃葡萄糖基酯（congmuyenoside I，1）、3-O-[β-D-吡喃葡萄糖基(1→2)-β-D-吡喃葡萄糖基]齐墩果酸 28-O-β-D-吡喃葡萄糖基酯（congmuyenoside II，2）、3-O-{[β-D-吡喃葡萄糖基(1→2)]-[β-D-吡喃葡萄糖基(1→3)-β-D-吡喃葡萄糖基(1→3)]-β-D-吡喃葡萄糖基}羽扇豆醇 28-O-β-D-吡喃葡萄糖基酯（congmuyenoside III，3）和 3-O-β-D-吡喃葡萄糖基蝙蝠葛醇 28-O-β-D-吡喃葡萄糖基酯（congmuyenoside IV，4），以及八种已知的三萜皂苷（5-12）。结构鉴定是通过光谱分析，特别是（13）C NMR、2D NMR 和 HR-ESI-MS 技术完成的。此外，化合物 5-10 是首次在多蕊木属中发现的。化合物 1-12 被测试了对 HL60、A549 和 DU145 癌细胞生长的抑制作用。此外，化合物 8 对 HL60、A549 和 DU145 癌细胞表现出显著的细胞毒性活性，IC50 值分别为 15.62、11.25 和 7.59 μM。
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