Department of Chemical Sciences, University Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, Napoli 80126, Italy.
Molecules. 2013 Dec 4;18(12):14892-919. doi: 10.3390/molecules181214892.
Gymnema sylvestre R. Br., one of the most important medicinal plants of the Asclepiadaceae family, is a herb distributed throughout the World, predominantly in tropical countries. The plant, widely used for the treatment of diabetes and as a diuretic in Indian proprietary medicines, possesses beneficial digestive, anti-inflammatory, hypoglycemic and anti-helmentic effects. Furthermore, it is believed to be useful in the treatment of dyspepsia, constipation, jaundice, hemorrhoids, cardiopathy, asthma, bronchitis and leucoderma. A literature survey revealed that some other notable pharmacological activities of the plant such as anti-obesity, hypolipidemic, antimicrobial, free radical scavenging and anti-inflammatory properties have been proven too. This paper aims to summarize the chemical and pharmacological reports on a large group of C-4 gem-dimethylated pentacyclic triterpenoids from Gymnema sylvestre.
武靴藤（Gymnema sylvestre R. Br.），夹竹桃科最重要的药用植物之一，是一种分布于世界各地的草本植物，主要分布在热带国家。该植物被广泛用于治疗糖尿病，并在印度专利药物中用作利尿剂，具有有益的消化、抗炎、降血糖和抗蠕虫作用。此外，它被认为对消化不良、便秘、黄疸、痔疮、心脏病、哮喘、支气管炎和白癜风的治疗有用。文献综述表明，该植物的一些其他显著的药理活性，如抗肥胖、降血脂、抗菌、清除自由基和抗炎特性也已得到证实。本文旨在总结武靴藤中一大类 C-4 位亚甲基二甲基化的五环三萜类化合物的化学和药理学研究进展。
