Saveetha Dental College and Hospitals, 162, Poonamalle High Road, Velappanchavadi, Chennai 600077, Tamil Nadu, India.
Int J Oral Maxillofac Surg. 2013 Mar;42(3):352-5. doi: 10.1016/j.ijom.2012.10.036. Epub 2012 Dec 21.
The goal of this study was to determine the efficacy of one dose and a short course (3 doses) of amoxycillin therapy for the prevention of infection following bilateral sagittal split osteotomy (BSSO). Patients who qualified for the trial were randomly divided into two groups: group I patients were given a single injection of amoxycillin 1.0 g administered preoperatively followed by two postoperative doses of saline four hourly (single dose group); group II patients were given single injection amoxycillin 1.0 g administered preoperatively followed by two postoperative doses of amoxycillin 0.5 g four hourly. The 60 patients included in this study were divided into two groups of 30. The patients were evaluated for 2 months for postoperative infections. In the postoperative period, six patients required rescue antibiotics in the single dose group and one in the short course group (P=0.04). There was a statistical difference in the rates of infection between the two groups (P=0.04). The findings indicate that a short postoperative course of antibiotics is more effective than a single preoperative dose for the prevention of infection following BSSO.
本研究的目的在于确定单次剂量和短疗程（3 剂）阿莫西林疗法预防双侧矢状劈开截骨术（BSSO）后感染的效果。符合试验条件的患者被随机分为两组：I 组患者给予单次 1.0 g 阿莫西林术前注射，随后每 4 小时给予两次生理盐水术后注射（单次剂量组）；II 组患者给予单次 1.0 g 阿莫西林术前注射，随后每 4 小时给予两次 0.5 g 阿莫西林术后注射。本研究共纳入 60 例患者，分为两组，每组 30 例。术后 2 个月评估患者的术后感染情况。在术后期间，单次剂量组有 6 例患者需要使用抗生素进行抢救，短疗程组有 1 例（P=0.04）。两组之间的感染率存在统计学差异（P=0.04）。研究结果表明，BSSO 术后短疗程抗生素治疗比单次术前剂量更能有效预防感染。
