Wallman C, Krasse B, Birkhed D
Department of Cariology, Faculty of Odontology, Göteborg University, Sweden.
Caries Res. 1994;28(6):435-40. doi: 10.1159/000262017.
The effect of antimicrobial treatment on the numbers of mutans streptococci (MS) in plaque from margins of restorations and in saliva was studied. Nineteen persons with well-restored dentitions and > 0.5 x 10(6) MS per ml saliva were treated with 1% chlorhexidine (CHX) gel in individually designed applicators 5 min/day for 9 days. Ten of the subjects continued the treatment with 0.4% stannous fluoride (SnF2) gel and the remaining 9 with a placebo gel for another 14 days. Plaque samples from margins of selected restorations and stimulated saliva were collected at baseline, after the completion of each gel treatment and then again at regular intervals up to 24 weeks. The CHX gel treatment suppressed MS in the margins of restorations as well as in saliva. Additional treatment with the SnF2 gel prolonged this suppression compared with CHX treatment alone. In the CHX-SnF2 group, the number of MS in margins of amalgam and composite restorations was still significantly lower at the end of the study compared with the baseline. In the CHX placebo group, the margins of amalgam restorations, mainly placed in premolars and molars, were recolonized somewhat faster than the margins of composite restorations in the front teeth.
研究了抗菌治疗对修复体边缘菌斑及唾液中变形链球菌（MS）数量的影响。19名牙列修复良好且唾液中MS含量>0.5×10⁶/ml的受试者，使用个体化设计的涂抹器，每天5分钟，用1%氯己定（CHX）凝胶治疗9天。其中10名受试者继续用0.4%氟化亚锡（SnF₂）凝胶治疗，其余9名用安慰剂凝胶再治疗14天。在基线、每次凝胶治疗结束时以及之后直至24周的定期时间点，收集选定修复体边缘的菌斑样本和刺激唾液。CHX凝胶治疗可抑制修复体边缘及唾液中的MS。与单独使用CHX治疗相比，额外使用SnF₂凝胶治疗可延长这种抑制作用。在CHX - SnF₂组中，研究结束时汞合金和复合树脂修复体边缘的MS数量仍显著低于基线水平。在CHX安慰剂组中，主要位于前磨牙和磨牙的汞合金修复体边缘的再定植速度比前牙复合树脂修复体边缘稍快。
