Ren Baosheng, Wang Wansheng, Shen Jian, Ni Caifang, Zhu Xiaoli
Department of Interventional Radiology, The First Affiliated Hospital of Soochow University Suzhou, China.
Department of Interventional Radiology, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou, China.
Am J Transl Res. 2019 Jul 15;11(7):4166-4179. eCollection 2019.
This study aimed to evaluate the operational performance, embolization effect and safety of CalliSpheres microspheres (CSM) in a porcine renal model. 24 healthy normal pigs were randomized into CSM group and Embosphere microspheres (ESM) group equally, and embolized with CSM or ESM in the lower pole of right kidneys, respectively. On D2, D7 and D28 after the operation, angiography and biochemistry examination were performed, and then the pigs were subjected to renal macroscopic and histopathological examination after euthanasia (4 pigs/group per each time point). The embolization was performed successfully in all pigs without obvious adverse events or deaths, and there was no difference in operation assessments (including number of embolized arteries, volume of injected microspheres and vessel recanalization rate) between CSM group and ESM group. After the operation, all pigs in CSM group and ESM group presented with renal necrosis, stasis and capsule exudation on D2 and D7, and capsule thickening, fibrosis and renal atrophy on D28, and there was no difference in these macroscopic or microscopic manifestations between two groups. For biochemistry indexes (including blood routine, coagulation function, liver function and renal function), most of them were similar between two groups at each time point. CSM embolizes porcine renal artery effectively and safely without obvious adverse events or deaths, which might be a good option for embolization therapy in clinical practices.
本研究旨在评估载药微球（CSM）在猪肾模型中的操作性能、栓塞效果及安全性。将24只健康正常猪随机均分为CSM组和栓塞微球（ESM）组，分别对其右肾下极进行CSM或ESM栓塞。术后第2天、第7天和第28天进行血管造影和生化检查，然后对猪实施安乐死后进行肾脏大体及组织病理学检查（每个时间点每组4只猪）。所有猪均成功进行栓塞，无明显不良事件或死亡发生，CSM组和ESM组在手术评估（包括栓塞动脉数量、注入微球体积和血管再通率）方面无差异。术后，CSM组和ESM组所有猪在第2天和第7天均出现肾坏死、淤血和包膜渗出，在第28天出现包膜增厚、纤维化和肾萎缩，两组在这些大体或微观表现上无差异。对于生化指标（包括血常规、凝血功能、肝功能和肾功能），两组在每个时间点的大多数指标相似。CSM能有效、安全地栓塞猪肾动脉，无明显不良事件或死亡发生，这可能是临床栓塞治疗的一个良好选择。
